Table 1:

Demographics and clinical characteristics of both groups

CharacteristicAIFR GroupControl GroupP Value
Age (yr)a49.5 ± 21.2 (2–85)46.7 ± 21.2 (2–75).54
Male2025
Female2217
White blood cell count (× 1000/mm3)a,b0.9 ± 1.5 (0–6)4.5 ± 12.4 (0.1–65.6).3
Absolute neutrophil count (× 1000/mm3)a,b0.51 ± 1.2 (0–4.9)1.8 ± 4.0 (0–20.3).66
No. of patients <500/mm3b60% (18/30)57.1% (20/35)
No. of patients <1000 mm3b83.3% (25/30)68.6% (24/35)
Time from CT to treatment (days)0.95 ± 1.10.83 ± 0.82.57
Follow-up time (days)a412.9 ± 587.5 (2–2836)346.7 ± 402.4 (18–2174).56
Deceased from AIFR7c0
Deceased not from AIFR149
Not deceased2033
Overall mortality52% (22/42)21% (9/42).003
AIFR-related mortality17% (7/41)a0% (0/42)
Non-AIFR related mortality34% (14/41)a21% (9/42)
  • a Data are reported as mean, with range in parentheses.

  • b Calculated only in patients with hematologic malignancy (including multiple myeloma) or bone marrow transplant.

  • c One patient was excluded because the cause of death was uncertain, reported as died with concomitant fulminant liver failure and AIFR.