Table 3:

Univariate analyses and multivariate logistic regression analysis for the association of early neurologic improvement after IV rtPA in patients with proximal middle cerebral artery occlusion

	Crude OR	P Value	Adjusted OR	P Value
	(95% CI)	P Value	(95% CI)	P Value
Age (yr)	0.99 (0.95–1.06)	.91	1.00 (0.94–1.06)	.95
Male sex	0.52 (0.16–1.63)	.26
History of atrial fibrillation	4.64 (1.20–23.36)	.025^{^a}	5.32 (1.16–32.1)	.031^{^a}
NIHSS score at arrival	1.04 (0.88–1.04)	.34	1.02 (0.89–1.09)	.72
DWI ASPECTS at arrival	1.16 (0.80–1.73)	.44
Time to rtPA administration	0.99 (0.97–1.02)	.49	1.00 (0.97–1.03)	.84
Development of collaterals at arrival^{^b}	4.0 (1.25–14.27)	.019^{^a}	4.82 (1.34–19.98)	.015^{^a}

↵a P < .05 was considered significant.
↵b The development of collaterals was defined as positive in the presence of PCA laterality positivity and an HV score of ≥5 on initial MRI.
c Adjusted for age, history of atrial fibrillation, NIHSS score at arrival, and time to rtPA administration.