Table 3:

Effects of age, APOE ϵ4, and sex on rates of change in MCI

MCI Measure	b₀	b_Cog	b_Edu	b_Age (SE; P)	b_APOE (SE; P)	b_Sex (SE; P)
Hippocampus	−1.83^{^a}	−0.13^{^a}	0.03	0.00 (.02; .8)	−0.40^{^a} (.20; .045)	−0.29 (.20; .1)
Amygdala	−1.57^{^a}	−0.15^{^a}	0.01	0.03 (.02; .1)	−0.94^{^a} (0.21; 7 × 10⁻⁶)	−0.98^{^a} (.21; 2 × 10⁻⁶)
Entorhinal	−1.78^{^a}	−0.12^{^a}	0.00	0.04^{^a} (.02; .006)	−0.44^{^a} (.17; .011)	−0.54^{^a} (.17; .002)
Inferior parietal	−0.91^{^a}	−0.08^{^a}	0.02	0.06^{^a} (.01; 2 × 10⁻⁶)	−0.28^{^a} (.14; .040)	−0.40^{^a} (.14; .004)
Middle temporal	−1.40^{^a}	−0.11^{^a}	0.00	0.07^{^a} (.02; 9 × 10⁻⁶)	−0.28 (.18; .1)	−0.52^{^a} (.17; .003)
Med-orbito-frontal	−0.78^{^a}	−0.04^{^a}	0.04^{^a}	0.02^{^a} (.01; .023)	0.03 (.11; .8)	−0.24^{^a} (.11; .026)
Whole brain	−0.74^{^a}	−0.04^{^a}	0.01	0.02^{^a} (.01; 4 × 10⁻⁴)	−0.09 (.08; .2)	−0.17^{^a} (.08; .022)
CDR-SB	0.46^{^a}	–	0.01	0.01 (.01; .4)	0.38^{^a} (.11; 6 × 10⁻⁴)	0.26^{^a} (.11; .021)
ADAS-Cog	0.49^{^a}	–	0.00	0.03 (.03; .3)	0.72^{^a} (.31; .022)	1.40^{^a} (.32; 2 × 10⁻⁵)
MMSE	−0.35^{^a}	–	0.02	0.02 (.02; .4)	−0.81^{^a} (.20; 4 × 10⁻⁵)	−0.34 (.20; .1)

Note:—See Table 2 for units and key.
↵a Values significant at P ≤ .05.
ROIs: N = 273; mean age = 76.65 years; mean ADAS-Cog = 11.68; mean years education = 15.61. Cognitive: N = 211; mean age = 76.84 years; mean years education = 15.63.