Efficacious acute stroke randomized controlled trials
| Trial | Time Window (hr) | Treatment | Screening Imaging Modality |
|---|---|---|---|
| NINDS1 | 0–3 | IV-tPA | NCCT |
| ECASS III2 | 3–4.5 | IV-tPA | NCCT |
| TNK25 | 0–6 | IV tenecteplase | NCCT+CTA+CTP |
| MR CLEAN3 | 0–6 | IA thrombectomy | NCCT+CTA/MRA/DSA |
| ESCAPE4 | 0–12 | IA thrombectomy | NCCT+multiphase CTA |
| EXTEND-IA5 | 0–6 | IA thrombectomy | NCCT+CTA+CTP |
| SWIFT-PRIME6 | 0–6 | IA thrombectomy | NCCT+CTA/MRA±CTP/MRP |
Note:—NINDS indicates National Institute of Neurological Disorders and Stroke; ECASS, European Cooperative Acute Stroke Study; TNK, tenecteplase; MR CLEAN, Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; IA, intra-arterial; MRP, MR perfusion.