Univariate and multivariate Cox survival analysis of clinical variables
| Univariate Cox | Multivariate Cox | |||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| TCGA test cohorta | ||||
| Age younger than 64 yr | 0.19 (0.26–0.55) | 4.1e–7b | 0.36 (0.24–0.53) | 3.7e–7b |
| Male sex | 1.05 (0.73–1.50) | .79 | – | – |
| CEL tumor volume (cm3) | ||||
| Large | 1.68 (1.10–2.54) | .015b | 1.80 (1.18–2.75) | .0064b |
| Intermediate | – | – | – | – |
| Small | 0.90 (0.58–1.37) | .62 | 1.11 (0.71–1.71) | .65 |
| Right laterality | 0.927 (0.65–1.32) | .67 | – | – |
| STR | 2.52 (0.73–8.68) | .14 | – | – |
| Tumor location = right periatrial location | 1.66 (1.03–2.67) | .036b | 2.0 (1.01–2.64) | .045b |
| Restricted set of intermediate and large tumorsc | ||||
| Age younger than 64 yr | 0.19 (0.26–0.55) | 4.1e–7 | 0.46 (0.30–0.72) | .00062 |
| Tumor location = right periatrial location | 1.84 (1.10–3.08) | .019 | 1.87 (1.11–3.15) | .018 |
Note:—HR indicates hazard ratio; STR, subtotal resection.
↵a Age, CEL tumor volume, and tumor location were independently significant in multivariate analysis (overall P < 3.52e–8). Surgical resection is subtotal resection or gross total resection, available for 24 cases in the TCGA test cohort.
↵b P value < .05, indicating the variable is significant.
↵c Tumor location remained significant in Cox analysis performed on the restricted set of intermediate and large tumors.