Proposed histopathologic interpretation based on signal-intensity changes on MR images
| Tissue Content | Susceptibility Effect | Signal Intensity on GRE-T2* | Signal Intensity on SWI | Signal Intensity on QSM |
|---|---|---|---|---|
| Calcium | Diamagnetism | Hypointense | Hypointense | Hypointense |
| Myelin | Diamagnetism | Isointense | Isointense | Isointense |
| Variable degree of micronecrosis, edema, gliosis, demyelination, and macromolecules | Diamagnetism | Hyperintense | Isointense or hyperintense | Isointense |
| Extensive degree of demyelination | Loss of diamagnetism (paramagnetism) | Hyperintense | Isointense or hyperintense | Hyperintense |
| Iron | Paramagnetism | Hypointense | Hypointense | Hyperintense |