Comparison of perfusion parameters between study groupsa
| HC (n = 19) | RRMS-NI (n = 19) | RRMS-I (n = 20) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WM | GM | WML | NAWM | CL | NAGM | WML | NAWM | CL | NAGM | |
| CBF | 21.8b | 44.0f | 14.4d,e | 21.5d,e | 21.4c | 41.1c,d,f | 12.5d,e | 17.0b,d,e | 23.1c | 31.7c,d,f |
| (mL/100 g per min) | (19.7–28.4) | (37.9–49.5) | (9.9–20.2) | (16.0–29.5) | (15.7–32.3) | (29.8–55.7) | (8.1–18.5) | (13.2–25.2) | (15.4–34.3) | (24.6–44.5) |
| CBV | 1.5b | 2.8f | 1.1d,e | 1.6d,e | 1.4c | 2.5c,d | 1.0d,e | 1.3b,d.e | 1.7c | 2.1c,d,f |
| (mL/100 g) | (1.2–1.9) | (2.1–3.2) | (0.8–1.6) | (1.2–2.1) | (1.1–2.0) | (1.9–3.4) | (0.7–1.4) | (1.0–1.7) | (1.2–2.4) | (1.7–2.7) |
| MTT | 4.3b | 3.8f | 4.8e | 4.6e | 4.3 | 3.9d,f | 5.0e | 4.8b,e | 4.6c | 4.0c,d,f |
| (min) | (3.9–5.0) | (3.4–4.3) | (4.1–5.9) | (4.1–5.2) | (3.5–4.9) | (3.3–4.4) | (4.2–6.0) | (4.3–5.2) | (3.9–5.4) | (3.5–4.6) |
Note:—HC indicates healthy controls.
↵a Normal-appearing GM and WM tissues are compared across patients with RRMS who were cognitively unimpaired and impaired and with healthy controls with corrected P < .017 (ie, .05/3) identified as significantly different. Lesion perfusion was also independently compared across disease groups and with the corresponding normal-appearing tissue within each patient group with P < .05 identified as significantly different. The values represent medians; the interquartile range for values are giving in parentheses.
↵b HC WM vs NAWM.
↵c CL vs NAGM.
↵d RRMS-NI vs RRMS-I.
↵e WML vs NAWM.
↵f HC GM vs NAGM.