Clinical characteristics of patients who presented with type II lesionsa
| Patient | Sex/Age (yr) | Symptoms | Lesion Location | Lesion Size (cm) | Durationb (mo) | IDH1 Mutation | |
|---|---|---|---|---|---|---|---|
| Type III | Classic GB | ||||||
| 1 | M/48 | LOC | Left temporal | 2 × 1.2 | NA | 12 | − |
| 2 | F/40 | Syncope | Right insula and frontal operculum | 4 × 2.5 | NA | 11 | NS |
| 3 | F/32 | Speech | Left parietal | 2.5 × 2 | NA | 4 | − |
| 4 | M/33 | Headache, LOC | Right insular | 3.1 × 2.5 | NA | 4 | NS |
| 5 | F/58 | Gait disturbance, memory impairment | Right medial frontal | 4 × 3 | 10 | 13 | NS |
| 6 | M/48 | Focal seizure | Right parietal | 3.5 × 2.5 | 8 | 10 | + |
| 7 | F/78 | Headache | Right temporal | 2.5 × 1 | NA | 2 | − |
| 8 | M/41 | Focal seizure | Left temporal | 3 × 2 | 1 | 1.5 | − |
| 9 | M/40 | Generalized seizure | Left parietal | 3 × 2.8 | NA | NA | NS |
| 10 | M/71 | Visual TIA | Right occipital | 3 × 3 | 2 | NA | NS |
| 11 | M/27 | Focal seizure | Left frontal | 2.2 × 2.8 | NA | NA | + |
Note:—LOC indicates loss of conscious; NA, not available; NS, not studied; +, positive; −, negative.
↵a The lesions refer to the FLAIR/T2-weighted hyperintensities involving both cortical GM and subcortical WM.
↵b The duration is the time interval between the first and follow-up MR imaging studies showing a type III lesion or classic GB. NA indicates that the particular lesion type was not detected during follow-up. The type II lesions of patients 9 and 11 were resected before they transformed to type III lesions or classic GB.