PD | MSA-P | PSP | |||||||
---|---|---|---|---|---|---|---|---|---|
FA | MD | R2* | FA | MD | R2* | FA | MD | R2* | |
Striatal and related structures | |||||||||
PUT | ↑↑a | ↑ | |||||||
CN | |||||||||
GP | ↑↑↑a | ↑ | ↑ | ↑ | |||||
Midbrain structures | |||||||||
antSN | ↓ | ↑ | ↑↑ | ↑ | |||||
postSN | ↓↓ | ↑ | ↑↑ | ↓ | ↑ | ↑↑↑↑a | ↑↑ | ||
RN | ↑↑a | ↓ | ↑ | ↑ | ↑↑a | ||||
STN | ↓↓a | ↑ | ↑↑↑a | ↑ | |||||
Limbic structures | |||||||||
Hipp | ↓ | ↑↑↑↑a | ↓ | ||||||
AM | ↓ | ↓ | ↑↑ | ||||||
Cerebellar structures | |||||||||
DN | ↓ | ↑↑a | |||||||
CB | ↓↓ | ↑↑↑a | ↓↓a | ↑↑a | |||||
SCP | ↓↓↓↓a | ↑↑↑↑a | |||||||
MCP | ↓ | ↑↑↑a | ↓↓↓a | ↑↑a |
Note:—antSN indicates anterior substantia nigra; postSN, posterior substantia nigra; Hipp, hippocampus; AM, amygdala; CB, cerebellum; DN, dentate nucleus; GP, globus pallidus; MCP, middle cerebellar peduncle; SCP, superior cerebellar peduncle.
↵a Statistical significance after Bonferroni correction (P < .0038, considering 13 independent tests). Upward arrows indicate increased MRI measures compared with controls, and downward arrows indicate decreased MRI measures compared with controls. ↑ represents P < .05, ↑↑ represents P < .01, ↑↑↑ represents P < .001, and ↑↑↑↑ represents P <0 .0001.