Table 2:

Individual MRI measurements in PD, MSA-P, and PSP compared with controls in different structures

PDMSA-PPSP
FAMDR2*FAMDR2*FAMDR2*
Striatal and related structures
    PUT↑↑a
    CN
    GP↑↑↑a
Midbrain structures
    antSN↑↑
    postSN↓↓↑↑↑↑↑↑a↑↑
    RN↑↑a↑↑a
    STN↓↓a↑↑↑a
Limbic structures
    Hipp↑↑↑↑a
    AM↑↑
Cerebellar structures
    DN↑↑a
    CB↓↓↑↑↑a↓↓a↑↑a
    SCP↓↓↓↓a↑↑↑↑a
    MCP↑↑↑a↓↓↓a↑↑a
  • Note:—antSN indicates anterior substantia nigra; postSN, posterior substantia nigra; Hipp, hippocampus; AM, amygdala; CB, cerebellum; DN, dentate nucleus; GP, globus pallidus; MCP, middle cerebellar peduncle; SCP, superior cerebellar peduncle.

  • a Statistical significance after Bonferroni correction (P < .0038, considering 13 independent tests). Upward arrows indicate increased MRI measures compared with controls, and downward arrows indicate decreased MRI measures compared with controls. ↑ represents P < .05, ↑↑ represents P < .01, ↑↑↑ represents P < .001, and ↑↑↑↑ represents P <0 .0001.