Imaging biomarkers for adult medulloblastoma genetic entity differentiationa
| Imaging Biomarker | P Value | Genetic Entity | ||
|---|---|---|---|---|
| SHH (n = 19) | WNT (n = 4) | Group 4 (n = 5) | ||
| Hydrocephalus | .03b | 12/19 | 0 | 4/5 |
| Chang M-stage ≥2 (CET1WI) | .02b | 10/19 | 0 | 1/5 |
| Hemorrhage | .04b | 0 | 0 | 2/5 |
| Contact with fourth ventricle | .02b | 3/19 | 3/4 | 3/5 |
| Contact with lower rhombic lip | .03b | 0 | 1/4 | 2/5 |
| Chang T-stage >2 (T2WI) | .01b | 17/19 | 1/4 | 4/5 |
| Tumor volume on T2WI (median and 95% CI) | .06c | 30.6 cm3 (26.6–37.7 cm3) | 5.6 cm3 (5.2–22.3 cm3) | 25.0 cm3 (0.64–47.4 cm3) |
Note:—SHH indicates sonic hedgehog–activated medulloblastoma (only TP53 wild type in this cohort); WNT, wingless-activated medulloblastoma.
↵a Candidate imaging biomarkers for the differentiation of 3 different genetic medulloblastoma entities in this cohort (SHH, WNT, non-SHH/non-WNT Group 4) are listed on the left.
↵b Significant.
↵c Near significance when comparing all 3 groups.