Iron content (micrograms of iron/gram of tissue) of each region in bvFTD, PPA, and the control group
| Region | Controls | bvFTD | PPA | Bonferroni-Corrected P Valuea | ||
|---|---|---|---|---|---|---|
| bvFTD vs Controls | PPA vs Controls | bvFTD vs PPA | ||||
| LSFG | 13.17 ± 5.78 | 24.35 ± 10.02 | 18.61 ± 4.23 | <.001b | .123 | .09 |
| RSFG | 12.55 ± 5.51 | 25.36 ± 9.82 | 18.45 ± 5.11 | <.001b | .75 | .03b |
| LPCG | 35.16 ± 10.03 | 40.17 ± 7.39 | 37.14 ± 8.28 | .064 | 1.00 | .914 |
| RPCG | 33.46 ± 14.29 | 41.74 ± 7.1 | 39.2 ± 12.11 | .012b | .416 | 1.00 |
| LAC | 17.21 ± 7.71 | 21.31 ± 5.72 | 18.57 ± 4.21 | .034b | 1.00 | .634 |
| RAC | 16.72 ± 5.7 | 22.15 ± 6.1 | 17.97 ± 3.79 | .001b | 1.00 | .092 |
| LIN | 12.44 ± 5.4 | 15.91 ± 7.09 | 15.33 ± 5.33 | .074 | .512 | 1.00 |
| RIN | 11.86 ± 5.59 | 16.55 ± 7.83 | 14.14 ± 2.78 | .01b | .883 | .793 |
| LCAU | 25.76 ± 12.05 | 29.00 ± 12.46 | 27.19 ± 4.88 | .756 | 1.00 | 1.00 |
| RCAU | 24.96 ± 13.46 | 31.43 ± 13.79 | 25.87 ± 7.32 | .13 | 1.00 | .609 |
| LPUT | 20.96 ± 11.23 | 26.98 ± 8.95 | 21.18 ± 5.33 | .037b | 1.00 | .227 |
| RPUT | 20.61 ± 9.5 | 27.84 ± 8.12 | 21.13 ± 6.49 | .003b | .06 | .066 |
| LGP | 27.58 ± 10.25 | 30.66 ± 9.08 | 28.39 ± 7.58 | .55 | 1.00 | 1.00 |
| RGP | 26.65 ± 7.27 | 32.3 ± 11.51 | 28.11 ± 8.68 | .053 | 1.00 | .585 |
| LFWM | 13.96 ± 6.61 | 14.67 ± 5.91 | 15.21 ± 3.17 | 1.00 | 1.00 | 1.00 |
| RFWM | 13.65 ± 5.98 | 17.08 ± 6.77 | 13.30 ± 4.64 | .078 | 1.00 | .217 |
| LHP | 12.28 ± 7.60 | 15.64 ± 7.07 | 15.58 ± 4.09 | .156 | .493 | 1.000 |
| RHP | 11.95 ± 6.6 | 17.01 ± 8.82 | 14.89 ± 4.21 | .024b | .671 | 1.00 |
| LTP | 13.72 ± 5.44 | 21.90 ± 8.69 | 19.67 ± 5.16 | <.001b | .041b | 1.00 |
| RTP | 13.25 ± 5.9 | 23.41 ± 8.71 | 18.77 ± 4.35 | <.001b | .07 | .166 |
| LRN | 27.29 ± 11.07 | 30.39 ± 10.99 | 27.90 ± 7.99 | .709 | 1.00 | 1.00 |
| RRN | 24.21 ± 9.13 | 31.58 ± 12.66 | 24.69 ± 9.05 | .02b | 1.00 | .177 |
| LSN | 26.78 ± 11.63 | 30.90 ± 9.90 | 28.05 ± 10.64 | .365 | 1.00 | 1.00 |
| RSN | 26.64 ± 12.49 | 31.0 ± 11.25 | 27.85 ± 11.09 | .403 | 1.00 | 1.00 |
| LDN | 20.71 ± 8.84 | 23.26 ± 7.86 | 21.41 ± 7.47 | .633 | 1.00 | 1.00 |
| RDN | 19.93 ± 6.5 | 24.03 ± 8.41 | 20.47 ± 3.96 | .064 | 1.00 | .424 |
Note:—RTP indicates right temporal pole; LTP, left temporal pole; LIN, left insula; RIN, right insula; LCAU, left caudate; RCAU, right caudate; RPUT, right putamen; LPUT, left putamen; LGP, left globus pallidus; RGP, right globus pallidus; LFWM, left frontal white matter; RFWM, right frontal white matter; LHP, left head and body of the hippocampus; RHP, right head and body of the hippocampus; LRN, left red nucleus; RRN, right red nucleus; RSN, right substantia nigra; LSN, left substantia nigra; RSFG, right superior frontal gyrus; LSFG, left superior frontal gyrus; LDN, left dentate nucleus; RDN, right dentate nucleus; RPCG, right precentral gyrus just anterior to central sulcus; LPCG, left precentral gyrus just anterior to central sulcus; LAC, left gray matter abutting and posterior to the cingulate sulcus along with adjacent medial frontal lobe; RAC, right gray matter abutting and posterior to the cingulate sulcus along with adjacent medial frontal lobe.
↵a Bonferroni post hoc tests compare differences among groups.
↵b Significant.