Table 1:

Patienta and tumor characteristics

CharacteristicsHPV− HNSCC (n = 84)HPV+ HNSCC (n = 21)P Valueb
Average age (range), yr65 (45–87)61 (45–73).15c
Sex, no. (%)
    Women23 (27)7 (33)
    Men61 (73)14 (67).79d
Tumor location, no. (%)
    Oral cavity50 (60)3 (14)
    Oropharynx34 (40)18 (86)<.001d
T classification according to AJCC 2017, no. (%)f
    T15 (6)1 (5)
    T222 (26)6 (29)
    T315 (18)3 (14)
    T442 (50)11 (52)1e
N classification according to AJCC 2017, no. (%)
    N036 (43)4 (19)
    N113 (15)6 (29)
    N235 (42)9 (43)
    N30 (0)2 (9).012e
M classification according to AJCC 2017, no. (%)
    M077 (92)18 (86)
    M11 (1)1 (5)
    Mx6 (7)2 (9).47e
Tumor keratinization, no. (%)
    Present65 (77)8 (38)
    Absent19 (23)13 (62).001d
Degree of keratinization, no. (%)
    Keratinizing48 (57)3 (14)
    Focally keratinizing17 (20)5 (24)<.001e
    Nonkeratinizing, no. (%)19 (23)13 (62)
Histologic differentiation, no. (%)
    Well differentiated15 (18)Not assessablef
    Moderately differentiated48 (57)
    Poorly differentiated21 (25)
Semiquantitative histologic score, no. (%)g
    Score 1 (most heterogeneous)14 (17)0 (0)
    Score 28 (9)0 (0)
    Score 341 (49)7 (33).002e
    Score 412 (14)5 (24)
    Score 5 (most homogeneous)9 (11)9 (43)
Mean proliferation index, MIB-1 (%)h4971.005c
    Range in %8–9030–95
  • Note:—AJCC indicates American Joint Committee on Cancer.

  • a Total patients, 105.

  • b P values are indicated for the comparisons between HPV+ and HPV− HNSCCs.

  • c Wilcoxon rank sum test.

  • d Pearson χ2 test.

  • e Fisher test.

  • f HPV+ HNSCC was not graded according to AJCC 2017 guidelines.3

  • g The semiquantitative histologic score is described in On-line Table 1.

  • h Available in 95 histologic samples.