Lobar GM and WM volume differences among HCs and subjects with RRMS and SPMS after adjusting for confounding factorsa
| Parameter | Median (Interquartiles) | P Value | ||||
|---|---|---|---|---|---|---|
| HC (n = 19) | RRMS (n = 19) | SPMS (n = 19) | RRMS vs HC (n = 19) | SPMS vs HC (n = 19) | SPMS vs RRMS (n = 19) | |
| Gray matter | ||||||
| Frontal lobe | 200.040 (190.352–167.944) | 199.248 (192.480–207.896) | 200.352 (193.500–207.540) | .69 | .60 | .22 |
| Parietal lobe | 90.296 (83.992–94.512) | 89.824 (85.048–95.176) | 93.368 (88.956–96.352) | .72 | .03 | .095 |
| Temporal lobe | 122.740 (110.640–130.560) | 121.336 (114.672–128.544) | 106.892 (99.432–112.928) | .86 | .0044b | .0073b |
| Occipital lobe | 101.088 (98.536–106.272) | 97.160 (95.728–102.960) | 72.792 (69.868–75.196) | .10 | .0030b | .0033b |
| White matter | ||||||
| Frontal lobe | 190.568 (170.368–201.528) | 170.316 (159.520–189.112) | 146.260 (134.908–157.136) | <.0001b | .0006b | <.0001b |
| Parietal lobe | 101.200 (94.536–109.152) | 93.272 (84.944–97.208) | 81.952 (77.736–87.532) | .0001b | .0018b | <.0001b |
| Temporal lobe | 70.132 (56.648–79.352) | 68.512 (64.116–74.016) | 61.208 (51.576–71.720) | .026 | .98 | .0026b |
| Occipital lobe | 32.024 (30.248–35.092) | 29.092 (24.136–33.768) | 26.864 (23.552–31.832) | .65 | .0098b | .0003b |
↵a Bonferroni-corrected P < .017 is considered statistically significant. Age was considered a confounding factor for comparing RRMS vs HC and SPMS vs HC; age, EDSS, and disease duration were considered confounding factors for comparing SPMS vs RRMS. All volumes are in cubic centimeters.
↵b Significant.