Baseline characteristics and workflow in subjects with last seen healthy to randomization time >5.5 hours
| Intervention (n = 33) | Control (n = 26) | |
|---|---|---|
| Demographics | ||
| Age (median) (IQR) (yr) | 66.1 (15.2) | 67.9 (21.9) |
| Female sex | 60.6% (20) | 42.3% (11) |
| Caucasian race | 87.9% (29) | 92.3% (24) |
| Medical history | ||
| Hypertension | 66.7% (22) | 80.8% (21) |
| Diabetes mellitus | 15.2% (5) | 26.9% (7) |
| Atrial fibrillation | 42.4% (14) | 42.3% (11) |
| Clinical characteristics | ||
| NIHSS score (median) (IQR) | 14 (4) | 17 (12) |
| Systolic blood pressure at hospital arrival (median) (IQR) (mm Hg) | 143 (22) | 138 (43) |
| Serum glucose at hospital arrival (median) (IQR) (mmol/L) | 6.8 (2.2) | 6.9 (2.0) |
| Imaging characteristics | ||
| ASPECTS on baseline noncontrast CT (median) (IQR) | 9 (2) | 8.5 (3) |
| Location of occlusion on CTAa | ||
| ICA with involvement of the M1 MCA segment (n = 16) | 29.0% (9/31) | 26.9% (7/26) |
| M1 or all M2 MCA segments (n = 40) | 67.7% (21/31) | 73.1% (19/26) |
| Single M2 MCA segment (n = 1) | 3.2% (1/31) | 0% (0/26) |
| Process time (min) | ||
| Stroke onset to randomization (median) (IQR) | 468 (179) | 405 (107) |
| Treatment | ||
| IV alteplase | 24.2% (8/33) | 57.8% (15/26) |
Note:—IQR indicates interquartile range.
↵a Two scans missing or not scoreable reduces the denominator to 31 in the intervention group.