Table 3:

DTI derivate metrics in patients with MNGIE and healthy controls

ROI	MD (Mean ± SD)	FA (Mean ± SD)	AD (Mean ± SD)	RD (Mean ± SD)
PO-WM
MNGIE	1.09 ± 0.16	0.27 ± 0.05	1.40 ± 0.16	0.93 ± 0.16
Controls	0.79 ± 0.05	0.40 ± 0.02	1.14 ± 0.07	0.61 ± 0.05
P Value^{^a}	<.0001^{^b}	<.0001^{^b}	.0001^{^b}	<.0001^{^b}
OR
MNGIE	1.15 ± 0.20	0.41 ± 0.07	1.69 ± 0.19	0.88 ± 0.21
Controls	0.81 ± 0.05	0.59 ± 0.09	1.35 ± 0.12	0.54 ± 0.06
P Value^{^a}	<.0001^{^b}	.0003^{^b}	.0002^{^b}	<.0001^{^b}
PLIC
MNGIE	0.78 ± 0.06	0.61 ± 0.07	1.40 ± 0.06	0.47 ± 0.08
Controls	0.69 ± 0.05	0.70 ± 0.04	1.36 ± 0.11	0.35 ± 0.05
P Value^{^a}	.0019^{^b}	.0008^{^b}	0.36	.0003^{^b}
CC
MNGIE	0.88 ± 0.08	0.66 ± 0.06	1.64 ± 0.11	0.49 ± 0.10
Controls	0.81 ± 0.09	0.76 ± 0.06	1.72 ± 0.19	.35 ± 0.08
P Value^{^a}	.12	.0012^{^b}	0.37	.0028^{^b}

Note:—OR indicates optic radiation; CC, corpus callosum.
↵a Statistical significance was set at P < .003 after Bonferroni correction for multiple comparisons.
↵b Significant.