Imaging features of initial metastases with respect to their molecular group assignmenta
| MRI Signals | Initial Metastasis (n = 25) | ||||
|---|---|---|---|---|---|
| WNT (n = 0) (%) | SHH (n = 3) (%) | Group 3 (n = 8) (%) | Group 4 (n = 14) (%) | P Valueb | |
| Ependymal C−/D+ | 0 (0) | 0 (0) | (0) | 6 (42.8) | .01c |
| 3rd V.I.R, C−/D+d | 0 (0) | (0) | (0) | 4 (28.6) | .02c |
| Ependymal C+/D+ | 0 (0) | 0 (0) | 3 (37.5) | 0 (0) | .02c |
| Leptomeningeal C−/D+ | 0 (0) | 0 (0) | 0 (0) | 3 (21.4) | .05 |
| Leptomeningeal C+/D+ | 0 (0) | 3 (100) | 5 (62.5) | 5 (35.7) | .17 |
| Leptomeningeal C+/D− | 0 (0) | 0 (0) | 0 (0) | 4 (28.6) | .02c |
Note:—C− indicates no contrast enhancing; D+, diffusion-restricting; D−, no diffusion-restricting; C+, contrast-enhancing; 3rd V.I.R, third ventricle infundibular recess.
↵a The sum of metastases in some locations is higher than the total number of patients in the group because each case could have multiple metastases in >1 compartment.
↵b P value determined using the Fisher exact test.
↵c Statistically significant.
↵d Subgroup of patients with mismatching ependymal metastasis in the third ventricle infundibular recess.