Diagnostic performance of morphologic MRI alone, quantitative DWI alone, qualitative DWIMRI, and quantitative DWIMRI with ADCmean < 1.22 × 10−3 mm2/s
| Morphologic MRI | Quantitative DWI with ADCmean < 1.22 | Morphologic MRI with Qualitative DWI | Morphologic MRI with Quantitative DWI (ADCmean < 1.22) | |
|---|---|---|---|---|
| TP (No.) | 30 | 30 | 34 | 35 |
| TN (No.) | 52 | 56 | 59 | 62 |
| FP (No.) | 13 | 9 | 6 | 3 |
| FN (No.) | 8 | 8 | 4 | 3 |
| Sensitivity (%)a | 78.9 | 78.9 | 89.4 | 92.1 |
| (95% CI) | (65.9–91.9) | (65.9–91.9) | (79.7–99.2) | (83.5–100.0) |
| Specificity (%)b | 80.0 | 86.1 | 90.8 | 95.4 |
| (95% CI) | (70.3–89.7) | (74.8–93.1) | (83.7–97.8) | (90.3–100.0) |
| PPV (%) | 69.7 | 76.9 | 85.0 | 92.1 |
| (95% CI) | (56.1–83.5) | (60.3–88.3) | (73.9–96.1) | (83.5–100.0) |
| NPV (%) | 86.6 | 87.5 | 93.6 | 95.4 |
| (95% CI) | (78.1–95.3) | (76.3–94.1) | (87.6–99.6) | (90.2–100.0) |
| LR+c | 3.94 | 5.70 | 9.69 | 19.9 |
| (95% CI) | (2.36–6.59) | (3.04–10.68) | (4.48–20.9) | (6.58–60.5) |
| LR−d | 0.26 | 0.24 | 0.11 | 0.08 |
| (95% CI) | (0.14–0.49) | (0.13–0.45) | (0.04–0.29) | (0.03–0.24) |
Note:—TP indicates true-positive; TN, true-negative; FP, false-positive; FN, false-negative; PPV, positive predictive value; NPV, negative predictive value.
↵a Comparison of sensitivities: MRI vs DWI: P = 1; MRI vs qualitative DWIMRI: P = .10; MRI vs quantitative DWIMRI: P = .025; qualitative DWIMRI vs quantitative DWIMRI: P = .31; DWI vs quantitative DWIMRI: P = .05.
↵b Comparison of specificities: MRI vs DWI: P = .34; MRI vs qualitative DWIMRI: P = .05; MRI vs quantitative DWIMRI: P = .004; qualitative DWIMRI vs quantitative DWIMRI: P = .18; DWI vs quantitative DWIMRI: P = .03.
↵c Comparison of LR+: MRI vs DWI: P = .36; MRI vs qualitative DWIMRI: P = .03; MRI vs quantitative DWIMRI: P = .004; qualitative DWIMRI vs quantitative DWIMRI: P = .17; DWI vs quantitative DWIMRI: P = .02.
↵d Comparison of LR−: MRI vs DWI: P = .85; MRI vs qualitative DWIMRI: P = .06; MRI vs quantitative DWIMRI: P = .01; qualitative DWIMRI vs quantitative DWIMRI: P = .24; DWI vs quantitative DWIMRI: P = .04.