Table 2:

Annualized atrophy and change in tract disruption^{^a}

	% Atrophy, MS	% Atrophy, HC	P (ANCOVA)	Δ Tract Disruption, MS	P (1-Sample)
Left thalamus	−1.22 ± 1.01	−0.78 ± 0.77	.006^{^b}	0.0051 ± 0.0236	.005^{^b}
Right thalamus	−1.06 ± 0.93	−0.81 ± 0.80	.090	0.0052 ± 0.0204	.001^{^b}
Left caudate	−0.92 ± 1.33	−0.29 ± 2.10	.011^{^b}	0.0224 ± 0.0614	<.001^{^b}
Right caudate	−0.73 ± 1.58	−0.15 ± 2.11	.04^{^b}	0.0285 ± 0.0652	<.001^{^b}
Left putamen	−1.13 ± 1.46	−0.72 ± 1.01	.065	0.0115 ± 0.0307	<.001^{^b}
Right putamen	−0.98 ± 1.67	−0.68 ± 0.85	.245	0.0119 ± 0.0318	<.000^{^b}
Left globus pallidus	−1.90 ± 2.36	−0.72 ± 1.31	.001^{^b}	0.0030 ± 0.0165	.017^{^b}
Right globus pallidus	−1.85 ± 1.93	−0.60 ± 1.11	<.001^{^b}	0.0019 ± 0.0113	.029^{^b}
Left hippocampus	−1.27 ± 1.75	−0.69 ± 1.21	.040^{^b}	0.0015 ± 0.0095	.032^{^b}
Right hippocampus	−0.99 ± 1.80	−0.63 ± 1.52	.232	0.0047 ± 0.0162	<.00^{^b}
Left amygdala	−1.87 ± 3.03	−0.55 ± 2.11	.005^{^b}	0.0014 ± 0.0088	.040^{^b}
Right amygdala	−2.03 ± 3.22	−0.51 ± 2.99	.003^{^b}	0.0025 ± 0.0114	.004^{^b}
Left accumbens	−1.57 ± 4.76	−0.58 ± 3.29	.203	0.0011 ± 0.0079	.073
Right accumbens	−1.52 ± 5.10	0.20 ± 5.21	.051	0.0021 ± 0.0090	.002^{^b}

Note:—Δ Tract Disruption indicates longitudinal change in the disruption of connected WM tracts.
↵a Data are means unless otherwise indicated.
↵b Significant.