Clinical and US features and characteristics of thyroid nodules with benign cytology
| Positive for BRAF V600E Mutation | Negative for BRAF V600E Mutation | P | |
|---|---|---|---|
| No. of nodules | 36 | 256 | |
| Diagnosis | <.001 | ||
| Malignant | 31 | 6 | |
| Benign | 5 | 250 | |
| Age (mean) (yr) | 44.7 ± 11.3 | 47.3 ± 13.9 | .31 |
| Sex | <.001 | ||
| F | 2 | 229 | |
| M | 10 | 27 | |
| Mean size of nodules (mm) | 9.4 ± 3.7 | 11.8 ± 4.1 | .41 |
| 5–10 | 23 | 145 | |
| >10 | 13 | 112 | |
| No. of suspicious US features | <.001 | ||
| 1 | 11 | 243 | |
| 2 | 17 | 12 | |
| 3 | 7 | 1 | |
| 4 | 1 | 0 | |
| Echogenicity | .11 | ||
| Hyper- or isoechoic | 1 | 15 | |
| Hypoechoic | 30 | 229 | |
| Marked hypoechoic | 5 | 12 | |
| Margin | .18 | ||
| Circumscribed | 15 | 137 | |
| Not circumscribed | 21 | 119 | |
| Calcification | <.001 | ||
| No calcifications | 12 | 161 | |
| Microcalcification | 21 | 72 | |
| Macrocalcification | 3 | 23 | |
| Shape | <.01 | ||
| Parallel | 16 | 167 | |
| Taller-than-wide | 20 | 89 | |
| Evidence of extrathyroidal growth | 0 | 0 | |
| Pathologic adenopathy | 2 | 0 |