Table: Outcome measures for patients in DEFUSE 3

Outcome MeasuresThrombectomy with GA (n = 26)Thrombectomy with CS (n = 66)Med Therapy (n = 90)P GA vs CSP GA vs MedP CS vs Med
Primary outcome: functional independence at 90 days (No.) (%)6 (23)35 (53)15 (17).01.56<.001
Median score on modified Rankin Scale at 90 days (IQR)3.5 (3–5)2 (1–4)4 (3–6).047.22<.001
NIHSS score at 24 hr (IQR)15.5 (6–20)8 (4–13)16 (11–21).03.31<.001
NIHSS score at discharge or at days 5–7 (IQR)8 (4–12)4 (2–11)15 (7–21).13.01<.001
Safety outcomes (No.) (%)
    Death at 90 days5 (19)8 (12)23 (26).51.51.04
    Symptomatic intracranial hemorrhage1 (4)5 (8)4 (4).671.0.5
    Early neurologic deterioration2 (8)6 (9)12 (13)1.0.52.41
    Parenchymal hematoma type 23 (12)5 (8)3 (3).68.13.28
Imaging outcomes
    Median infarct volume at 24 hr (IQR) (mL)39.6 (21.1–132.3)33.6 (13.8–71.3)41.0 (25.4–106.2).37.83.12
    Median infarct growth at 24 hr (IQR) (mL)26.9 (12.9–104.8)22.3 (7.5–55.6)32.8 (18.3–74.8).35.75.04
    Reperfusion >90% at 24 hr (No.)/(total No.) (%)16/21 (76)43/54 (80)12/68 (18).76<.001<.001
    Complete recanalization at 24 hr (No.)/(total No.) (%)17/23 (74)48/60 (80)14/77 (18).56<.001<.001
    Reperfusion >90% and/or complete recanalization at 24 hr (No.)/(total No.) (%)17/24 (71)48/61 (79)14/80 (18).44<.001<.001
    TICI score of 2b or 3 (No.)/(total No.) (%)18/26 (69)52/66 (79)NA.33NANA
    Length of stay at enrolling hospital (days)8.02 (5.35–12.18)5.93 (3.31–8.85)8.94 (6.17–14.03).03.33<.001
Discharge destination.36.83.48
    Home3 (12)13 (20)14 (16).39.76.53
    Acute care facility2 (8)6 (9)4 (4)
    Skilled nursing facility7 (27)11 (17)18 (20)
    Acute rehab unit10 (38)26 (39)35 (39)
    Death3 (12)2 (3)9 (10)
    Other1 (4)8 (12)10 (11)
  • Note:—Med indicates medical management; rehab, rehabilitation.