Table 3:

Dependency of automated segmentation performance on MLVa

GroupThresholdsDicePrecisionbSensitivityCorrelation
I-AMLV < 1 cm3 (n = 22)31.0 (0–50.0)29.6 (3.4–54.9)57.5 (0–90.0)ρ = 0.09, P = .68
I-BMLV ≥ 1 cm3 (n = 129)83.5c (71.2–89.3)84.9c (70.3–92.9)87.6d (75.8–92.9)ρ = 0.90, P < .001
II-AMLV < 21 cm3 (n = 100)71.2 (45.8–84.8)71.6 (38.7–84.9)81.3 (59.8–92.5)ρ = 0.79, P < .001
II-BMLV ≥ 21 cm3 (n = 51)89.4c (85.4–92.5)92.3c (85.6–96.1)89.3e (83.0–92.2)ρ = 0.97, P < .001
III-AMLV < 31 cm3 (n = 113)73.6 (48.0–85.8)77.2 (46.3–85.7)82.5 (62.8–92.1)ρ = 0.83, P < .001
III-BMLV ≥ 31 cm3 (n = 38)90.6c (87.3–93.2)94.7c (88.4–96.8)89.4e (82.8–93.6)ρ = 0.96, P < .001
IV-AMLV < 51 cm3 (n = 124)75.0 (48.9–86.8)78.1 (49.2–86.5)83.3 (65.2–92.5)ρ = 0.87, P < .001
IV-BMLV ≥ 51 cm3 (n = 27)91.5c (89.1–93.6)95.9c (92.2–97.5)89.2 (83.5–92.2)ρ = 0.92, P < .001
V-AMLV < 70 cm3 (n = 131)77.2 (51.5–87.0)79.9 (54.2–87.0)84.0 (67.8–92.6)ρ = 0.88, P < .001
V-BMLV ≥ 70 cm3 (n = 20)91.8c (89.4–93.9)96.0 (93.0–96.9)89.6 (85.0–92.0)ρ = 0.83, P < .001
  • a Performance metrics are in median (IQR) and percentages. Results of E3 applied to the Evaluation Cohort are shown as a function of different volume thresholds.

  • b Excludes 2 subjects in group A with automatically segmented lesion volumes of zero because precision is undefined in this circumstance.

  • c P < .001.

  • d P < .01.

  • e P < .05 group A versus group B, where Group A is the group meeting the threshold criteria and Group B is the group not meeting the threshold criteria.