Outcome measures for patients in DEFUSE 3
| Outcome Measures | Thrombectomy with GA (n = 26) | Thrombectomy with CS (n = 66) | Med Therapy (n = 90) | P GA vs CS | P GA vs Med | P CS vs Med |
|---|---|---|---|---|---|---|
| Primary outcome: functional independence at 90 days (No.) (%) | 6 (23) | 35 (53) | 15 (17) | .01 | .56 | <.001 |
| Median score on modified Rankin Scale at 90 days (IQR) | 3.5 (3–5) | 2 (1–4) | 4 (3–6) | .047 | .22 | <.001 |
| NIHSS score at 24 hr (IQR) | 15.5 (6–20) | 8 (4–13) | 16 (11–21) | .03 | .31 | <.001 |
| NIHSS score at discharge or at days 5–7 (IQR) | 8 (4–12) | 4 (2–11) | 15 (7–21) | .13 | .01 | <.001 |
| Safety outcomes (No.) (%) | ||||||
| Death at 90 days | 5 (19) | 8 (12) | 23 (26) | .51 | .51 | .04 |
| Symptomatic intracranial hemorrhage | 1 (4) | 5 (8) | 4 (4) | .67 | 1.0 | .5 |
| Early neurologic deterioration | 2 (8) | 6 (9) | 12 (13) | 1.0 | .52 | .41 |
| Parenchymal hematoma type 2 | 3 (12) | 5 (8) | 3 (3) | .68 | .13 | .28 |
| Imaging outcomes | ||||||
| Median infarct volume at 24 hr (IQR) (mL) | 39.6 (21.1–132.3) | 33.6 (13.8–71.3) | 41.0 (25.4–106.2) | .37 | .83 | .12 |
| Median infarct growth at 24 hr (IQR) (mL) | 26.9 (12.9–104.8) | 22.3 (7.5–55.6) | 32.8 (18.3–74.8) | .35 | .75 | .04 |
| Reperfusion >90% at 24 hr (No.)/(total No.) (%) | 16/21 (76) | 43/54 (80) | 12/68 (18) | .76 | <.001 | <.001 |
| Complete recanalization at 24 hr (No.)/ (total No.) (%) | 17/23 (74) | 48/60 (80) | 14/77 (18) | .56 | <.001 | <.001 |
| Reperfusion >90% and/or complete recanalization at 24 hr (No.)/(total No.) (%) | 17/24 (71) | 48/61 (79) | 14/80 (18) | .44 | <.001 | <.001 |
| TICI score of 2b or 3 (No.)/(total No.) (%) | 18/26 (69) | 52/66 (79) | NA | .33 | NA | NA |
| Length of stay at enrolling hospital (days) | 8.02 (5.35–12.18) | 5.93 (3.31–8.85) | 8.94 (6.17–14.03) | .03 | .33 | <.001 |
| Discharge destination | .36 | .83 | .48 | |||
| Home | 3 (12) | 13 (20) | 14 (16) | .39 | .76 | .53 |
| Acute care facility | 2 (8) | 6 (9) | 4 (4) | |||
| Skilled nursing facility | 7 (27) | 11 (17) | 18 (20) | |||
| Acute rehab unit | 10 (38) | 26 (39) | 35 (39) | |||
| Death | 3 (12) | 2 (3) | 9 (10) | |||
| Other | 1 (4) | 8 (12) | 10 (11) |
Note:—Med indicates medical management; rehab, rehabilitation.