Survival analysisa
| Predictor | Ratio | Adjusted Hazard Ratio (95% CI) | P Value |
|---|---|---|---|
| All LGGs | |||
| Presurgical glioma volume | 3rd Q:1st Q | 1.14 (0.79–1.64) | .479 |
| Postsurgical glioma volume | 3rd Q:1st Q | 1.80 (1.18–2.75) | .006 |
| Percentage glioma resection | 25%:75% | 3.22 (1.79–5.82) | <.001 |
| IDHmut-Codel | |||
| Presurgical glioma volume | 3rd Q:1st Q | 1.11 (0.53–2.33) | .781 |
| Postsurgical glioma volume | 3rd Q:1st Q | 1.67 (0.82–3.48) | .170 |
| Percentage glioma resection | 25%:75% | 6.69 (1.57–28.46) | .010 |
| IDHmut-Noncodel | |||
| Presurgical glioma volume | 3rd Q:1st Q | 3.20 (1.22–8.39) | .018 |
| Postsurgical glioma volume | 3rd Q:1st Q | 2.33 (1.32–4.12) | .004 |
| Percentage glioma resection | 25%:75% | 4.34 (1.74–10.81) | .002 |
| IDHwt | |||
| Presurgical glioma volume | 3rd Q:1st Q | 2.18 (0.47–10.15) | .319 |
| Postsurgical glioma volume | 3rd Q:1st Q | 1.34 (0.28–4.76) | .653 |
| Percentage glioma resection | 25%:75% | 0.91 (0.29–2.82) | .874 |
Note:—Q indicates quartile.
↵a Predictor variables for overall survival are presurgical glioma volume, postsurgical glioma volume, and percentage glioma resection. Adjusted hazard ratios are listed for the entire cohort and for the 3 molecular subtypes, with age, sex, glioma grade, and chemotherapy and radiation therapy administration as the adjustment variables.