Regional volumes and mean intensity values for MRI parametersa
| WML | Penumbra (0–2 mm) | Penumbra (2–4 mm) | dNAWM | Regression Coefficient | |
|---|---|---|---|---|---|
| Mean volume (cm3) | 0.738 (0.842) | 2.78 (2.26) | 5.81 (4.21) | 219 (3.68) | NA |
| [0.661–0.815] | [2.57–2.99] | [5.43–6.19] | [186–253] | ||
| FLAIR intensity | 136 (10.1) | 98.9 (3.50) | 79.4 (3.71) | 70.8 (2.58) | −0.854 |
| [135–137] | [98.6–99.2] | [79.1–79.7] | [70.6–71.0] | ||
| T1 intensity | 116 (6.43) | 132 (5.80) | 142 (4.50) | 156 (1.31) | 0.824 |
| [115–117] | [132–133] | [142–142] | [156–156] | ||
| T2 intensity | 115 (8.62) | 88.3 (6.82) | 74.1 (4.75) | 60.6 (1.02) | −0.734 |
| [114–115] | [87.7–88.9] | [73.7–74.5] | [60.5–60.7] | ||
| FA | 0.279 (0.0554) | 0.328 (0.0411) | 0.374 (0.0380) | 0.384 (0.0254) | 0.630 |
| [0.273–0.284] | [0.324–0.331] | [0.371–0.377] | [0.382–0.386] | ||
| MD (10−3) | 3.68 (0.662) | 3.23 (0.445) | 2.97 (0.344) | 2.33 (0.112) | −0.578 |
| [3.62–3.73] | [3.19–3.27] | [2.93–3.00] | [2.32–2.34] | ||
| CBF (mL/100 g/min) | 25.2 (10.3) | 26.9 (9.37) | 28.8 (9.06) | 34.4 (8.56) | 0.306 |
| [24.3–26.1] | [26.1–27.7] | [28.0–29.6] | [33.6–35.2] | ||
| VR | 0.776 (0.493) | 0.779 (0.379) | 0.790 (0.328) | 0.681 (0.377) | 0.192 |
| (Mean % change) | [0.731–0.821] | [0.745–0.813] | [0.760–0.820] | [0.647–0.715] |
Note:—NA indicates not applicable.
↵a SD is in parentheses, and 95% confidence intervals for intensity parameters are in brackets. Kruskal-Wallis tests were significant for all parameters, and pair-wise comparisons had P < .001 except that the WML and penumbral ROIs did not show significant differences in VR. The slope of linear regression across the 4 regions for intensity variables using a median value is shown in the last column; regression analyses were all statistically significant with P < .001.