Table 1:

Baseline demographics at visit 2 and P values for association with concurrent carotid distensibility measurementa

VariableFull Cohort (n = 1402)P Value for Association with Carotid Distensibility
Age (mean)55.6 ± 5.3<.001d
Male (No.) (%)571, 40.7.214
Caucasian (No.) (%)1,023, 73.0.007d
Hypertension (No.) (%) (n = 1396)280, 20.1<.001d
Diabetes (No.) (%) (n = 1398)71, 5.1.265
History of myocardial infarction (No.) (%)26, 1.9.898
History of stroke (No.) (%)10, 0.7.602
Prevalent coronary heart disease (No.) (%)16, 1.2.297
Current cigarette smoking (No.) (%) (n = 1400)206, 14.7<.001d
Current alcohol consumption (No.) (%) (n = 1400)846, 60.4.009d
Body mass index (mean)27.1 ± 4.6<.001d
LDL cholesterol (mean) (mg/dL) (n = 1376)131.2 ± 35.0.493
HDL cholesterol (mean) (mg/dL) (n = 1328)49.3 ± 16.7.067
Fasting blood glucose (mean) (mmol/L)5.9 ± 1.6.077
Antihypertensive in last 2 weeks (No.) (%) (n = 1397)248, 17.8<.001d
Aspirin in last 2 weeks (No.) (%) (n = 1400)632, 45.1.369
Statin in last 2 weeks (No.) (%) (n = 1400)29, 2.1.651
Plaque in either carotid on ultrasound (No.) (%) (n = 1392)310, 22.3.270
Voltage of left ventricular leads on ECG (mean) (n = 1391)1174.2 ± 525.4<.001d
WMH volume (mean) (mL)17.5 ± 17.4
Total brain volume (mean) (mL) (n = 1397)b1015.8 ± 109.4
Ratio of WMH/TBV (mean) (%) (n = 1397)b1.7 ± 1.7
Mean systolic blood pressure (mm Hg)c135.0 ± 12.4
Mean systolic SD (mm Hg)c15.8 ± 4.2
Mean number of blood pressure readingsc23.3 ± 3.1
Years between carotid ultrasound and MRI (mean)21.5 ± 0.9
  • Note:—ECG indicates electrocardiography; HDL, high-density lipoprotein; LDL, low-density lipoprotein.

  • a Association tested with linear regression for continuous variables and Student t test for categoric variables.

  • b Derived from visit 5 MRI.

  • c Derived from all available blood pressure readings from visit 2 through visit 5.

  • d Significant.