Multiparametric values for anterolateral/posterolateral/total WM in HC and normal-appearing and lesional regions in patients with MSa
| ROI/MRI Metrics | HC (n = 19) | MS (n = 19) | |
|---|---|---|---|
| NA | Lesions | ||
| Anterolateral WM | |||
| ADC (10−3 mm2/s) | 1.04 ± 0.08 | 1.08 ± 0.14 | 1.11 ± 0.17 |
| FA (n.u) | 0.65 ± 0.04 | 0.62 ± 0.07 | 0.61 ± 0.06 |
| λ// (10−3 mm2/s) | 1.90 ± 0.08 | 1.92 ± 0.15 | 1.96 ± 0.19 |
| λ⊥ (10−3 mm2/s) | 0.60 ± 0.10 | 0.66 ± 0.15 | 0.69 ± 0.20 |
| ihMTR (%) | 5.88 ± 0.40 | 5.03 ± 0.62b,c | 4.30 ± 0.4c,d,e |
| MTR (%) | 32.04 ± 1.87 | 30.65 ± 2.25 | 29.69 ± 2.89f |
| Posterolateral WM | |||
| ADC (10−3 mm2/s) | 1.00 ± 0.08 | 1.00 ± 0.10 | 1.09 ± 0.18 |
| FA (n.u) | 0.69 ± 0.03 | 0.67 ± 0.08 | 0.65 ± 0.06f |
| λ// (10−3 mm2/s) | 1.95 ± 0.07 | 1.90 ± 0.11 | 2.05 ± 0.17e |
| λ⊥ (10−3 mm2/s) | 0.53 ± 0.10 | 0.56 ± 0.14 | 0.63 ± 0.20 |
| ihMTR (%) | 5.82 ± 0.39 | 5.11 ± 0.49b,c | 4.18 ± 0.70c,d,f |
| MTR (%) | 31.42 ± 1.23 | 30.12 ± 1.45 | 28.99 ± 2.57b |
| Total WM | |||
| ADC (10−3 mm2/s) | 1.01 ± 0.08 | 1.04 ± 0.10 | 1.09 ± 0.16 |
| FA (n.u) | 0.68 ± 0.03 | 0.66 ± 0.07 | 0.64 ± 0.05f |
| λ// (10−3 mm2/s) | 1.94 ± 0.07 | 1.93 ± 0.10 | 2.02 ± 0.16 |
| λ⊥ (10−3 mm2/s) | 0.55 ± 0.10 | 0.59 ± 0.13 | 0.64 ± 0.19 |
| ihMTR (%) | 5.84 ± 0.40 | 4.95 ± 0.55f | 4.27 ± 0.6 5c,d |
| MTR (%) | 31.58 ± 1.53 | 29.85 ± 1.56f | 29.32 ± 2.48f |
Note:—(n.u) indicates no unit.
↵a Values are reported as group mean ± SD. Significant differences between metrics from control subjects and NA tissue in patients with MS as well as between HC and lesional tissue were assessed with Steel-Dwass tests and are indicated with the P values below.
↵b P < .001.
↵c Differences that survived the Holm-Bonferroni correction for multiple comparisons.
↵d P < .0001.
↵e The only significant metric difference between NA and lesions in patients with MS (P = .003).
↵f P < .05.