Table 2:

Modified criteria for the diagnosis of RIS2

Inclusion CriteriaExclusion Criteria
≥1 T2-hyperintense lesions on T2-weighted scans involving at least 2 of the following 4 locations:
  1. Periventricular white matter

  2. Cortical/juxtacortical

  3. Spinal cord

  4. Infratentorial

Neurologic dysfunction suggestive of MS based on historical symptoms and/or objective signs
MR imaging abnormalities explained by other disease processes, especially considering age, vascular, toxins, or drug-related abnormalities