Intraindividual comparison of model-free and pharmacokinetic parameters between gadobutrol and gadoterate meglumine dynamic contrast-enhanced MR imaginga
| DCE Parameter | Gadobutrol | Gadoterate Meglumine | P Value |
|---|---|---|---|
| Model-free method | |||
| IAUC30 | 3.91 ± 2.38 | 4.27 ± 2.02 | .517 |
| IAUC100 | 21.50 ± 12.82 | 23.41 ± 11.28 | .530 |
| IAUC200 | 39.08 ± 23.30 | 42.53 ± 20.57 | .533 |
| IAUC300 | 56.68 ± 33.77 | 61.68 ± 29.88 | .533 |
| IAUC400 | 74.25 ± 44.24 | 80.79 ± 39.17 | .534 |
| IAUC500 | 91.84 ± 54.71 | 99.91 ± 48.46 | .534 |
| IAUC600 | 109.44 ± 65.19 | 119.06 ± 57.76 | .534 |
| IAUC700 | 127.04 ± 75.66 | 138.21 ± 67.07 | .535 |
| IAUC800 | 144.66 ± 86.13 | 157.37 ± 76.37 | .535 |
| IAUC900 | 166.69 ± 98.74 | 179.04 ± 83.13 | .656 |
| IAUC1000 | 184.76 ± 109.43 | 198.43 ± 92.13 | .656 |
| IAUC1100 | 202.85 ± 120.13 | 217.84 ± 101.13 | .657 |
| Pharmacokinetic method | |||
| Ktrans (min–1) | 0.016 ± 0.009 | 0.017 ± 0.008 | .592 |
| Kep (min–1) | 0.127 ± 0.042 | 0.132 ± 0.041 | .594 |
| Ve (%) | 17.797 ± 10.057 | 17.271 ± 7.436 | .813 |
| Vp | 1.168 ± 0.674 | 1.263 ± 0.600 | .559 |
| Wash-in rate | 0.825 ± 0.644 | 0.289 ± 0.634 | .013 |
| Washout rate | 0.0010 ± 0.0008 | 0.0021 ± 0.0025 | .024 |
↵a Data area means. P values are from paired tests when the variables satisfied normality according to the Shapiro-Wilk test or from Wilcoxon-signed rank tests otherwise.