Table 1:

Variability of iNPH biomarkers with respect to imaging plane angulation^{^a}

Biomarker	Mean		Repeated Measures ANOVA (P Values)
Biomarker	HC	iNPH	iNPH/HC	Angulation	Angulation iNPH/HC
DESH	0.12	1.31	<.001	.463	.463
simpCA	129.8	98.2	<.001	.264	.950
FHD	39.1	51.2	<.001	.151	.757
ZEI	0.286	0.420	<.001	.075	.792
CMW	17.4	34.5	<.001	.056	.49
BVR	2.44	0.92	<.001	.005	.106
THW	7.6	12.5	<.001	.002	.026
CTR	2.33	2.86	<.001	.002	.235
EI	0.293	0.384	<.001	<.001	.971
FHVD	25.7	38.8	<.001	<.001	.059
CA	116.6	74.7	<.001	<.001	<.001
SVW	39.6	30.9	<.001	<.001	.288

Note:—HC indicates healthy control; iNPH, idiopathic normal pressure hydrocephalus.
↵a Please refer to the Results section for detailed explanation. Two-way repeated measures ANOVA: angulation is a within-subjects factor (Angulation), and disease status is a between-subjects factor (iNPH/HC). Angulation by disease status interaction term (Angulation iNPH/HC) is significant for THW and CA only, with larger effects observed in the iNPH group for both biomarkers. Data are sorted in descending angulation P value order (column 5: “Angulation”). Decreasing P values indicate increasing statistical differences between measurements obtained at different section planes.