Baseline characteristics of subjects with CAA-MCI and those with non-CAA-MCI
| CAA-MCI (n = 24) | non-CAA-MCI (n = 62) | P Value | |
|---|---|---|---|
| Demographics | |||
| Age at NPT (mean) [SD] (yr) | 74.73 [5.99] | 73.25 [8.33] | .36 |
| Female (No.) (%) | 7 (29.2) | 26 (41.9) | .27 |
| Education (median) (IQR) (yr) | 16 (16, 18) | 16 (14, 18) | .04a |
| Vascular risk factors | |||
| Hypertension (No.) (%) | 13 (54.2) | 40 (64.5) | .38 |
| Diabetes (No.) (%) | 1 (4.2) | 10 (16.1) | .17 |
| Atrial fibrillation (No.) (%) | 4 (16.7) | 5 (8.1) | .26 |
| Dyslipidemia (No.) (%) | 13 (54.2) | 44 (71.0) | .14 |
| Neuropsychological performances | |||
| MMSE (median) (IQR) | 25.5 (24–28) | 28 (26–29) | .006a |
| MMSE (z score) (median) (IQR) | –1.88 (–3.28, –0.16) | 0 (–1.48–1.11) | .003a |
| Memory (z score) (median) (IQR) | –1.91 (–2.38, –0.75) | –0.47 (–1.60–0.56) | .005a |
| Processing speed (z score) (median) (IQR) | –0.24 (–0.62–0.15) | –0.11 (–0.46–0.27) | .34 |
| Language (z score) (median) (IQR) | –0.44 (–0.91–0.36) | –0.36 (–1.17–0.19) | .95 |
| Executive function (z score) (median) (IQR) | –0.59 (–1.89–0.22) | –0.21 (–0.86–0.12) | .20 |
| Imaging | |||
| PSMD (× 10–4 mm2/s) (median) (IQR) | 4.48 (3.81–5.09) | 3.63 (3.28–4.13) | <.001a |
| Lobar CMB count (median) (IQR) | 5.5 (3.0–24.50) | 0 (0–0) | <.001a |
| cSS (presence) (No.) (%) | 9 (37.5) | 0 (0.0) | <.001a |
| High CSO-PVS score (>2) (No.) (%) | 11 (45.8) | 3 (4.8) | <.001a |
| nWMHV (median) (IQR) | 0.42 (0.28–1.74) | 0.29 (0.14–0.75) | .02a |
| nTBV (mean) [SD] | 0.61 [0.04] | 0.64 [0.05] | .004a |
Note:—NPT indicates neuropsychological tests.
↵a Significant.