Neural Substrates of Spoken Language Rehabilitation in an Aphasic Patient: An fMRI Study

doi:10.1006/nimg.2002.1238

NeuroImage

Volume 17, Issue 1, September 2002, Pages 174-183

https://doi.org/10.1006/nimg.2002.1238 Get rights and content

Abstract

Little is known about the neural counterparts of speech therapy in aphasic patients. An fMRI experiment was performed before and after a specific and intensive speech output therapy in RC, a patient with long-lasting speech output deficit following a left-sided ischemic lesion. Overt picture naming and picture/word rhyming were used as activation tasks in RC and 6 control subjects. The naming task concerned the output lexicon deficit to be rehabilitated while rhyming referred to preserved levels of processing and was used to control for repetition effect. The speech therapy program improved naming performance. By comparison to the pattern observed before therapy, the naming task after therapy induced a pattern of activation close to that observed in control subjects, involving left-sided language areas surrounding the lesion. Speech therapy effect was associated with activations in Broca's area and the left supra-marginal gyrus, which might reflect a therapy-induced phonological compensatory strategy for naming.

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Regular ArticleNeural Substrates of Spoken Language Rehabilitation in an Aphasic Patient: An fMRI Study

Abstract

Neuropsychologia

Brain Lang.

NeuroImage

Lancet

Neuropsychologia

NeuroImage

J. Commun. Disord.

Brain Lang.

Brain Lang.

Brain Lang.

Lancet

Recovery from nonfluent aphasia after melodic intonation therapy: A PET study

Neurology

Regional cerebral blood flow during object naming and word reading

Hum. Brain Mapp

Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging

Proc. Natl. Acad. Sci. USA

Neural substrate for the effects of passive training on sensory motor cortical representation: A study with functional magnetic resonance imaging in healthy subjects

J. Cereb. Blood Flow Metab.

Plasticity of the adult human brain

Brain Mapping: The Systems

A neural basis for lexical retrieval

Nature

The token test: A sensitive test to detect receptive disturbances in aphasics

Brain

Diversity of patterns of improvement in confrontation naming rehabilitation: Some tentative hypotheses

J. Commun. Disord.

A new brain region for coordinating speech articulation

Nature

Le cerveau humain

The efficacy of group communication treatment in adults with chronic aphasia

J. Speech Lang. Hear. Res.

Diagnostic of conduction aphasia

Electropalatographic study of articulation disorders in verbal dyspraxia

Differential capacity of left and right hemispheric areas for compensation of poststroke aphasia

Ann. Neurol.

Treatment efficacy: Aphasia

J. Speech Hear. Res.

Word rhyming as a probe of hemispheric language dominance with functional magnetic resonance imaging

Neuropsychiatry Neuropsychol. Behav. Neurol.

Regular Article
Neural Substrates of Spoken Language Rehabilitation in an Aphasic Patient: An fMRI Study