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Potential Role of CT Perfusion Parameters in the Identification of Solitary Intra-axial Brain Tumor Grading

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Book cover Brain Edema XIV

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 106))

Abstract

In this study, neoplastic perfusion abnormalities were investigated by computed tomography perfusion (CTP) scanning in 38 patients with solitary intra-axial brain tumors (19 with high grade gliomas, 7 with low grade gliomas and 12 with brain metastasis). Regional cerebral blood flow (rCBF), cerebral blood volume (rCBV), mean transit time (rMTT) and permeability surface flow (rPSF) levels were measured in two different regions of interest: (1) enhancing or non-enhancing tumor tissue and (2) a mirror area of apparently normal brain tissue located in the contralateral hemisphere. rCBF mean levels were greater in tumoral tissue than in the contralateral area for high-grade gliomas (p < 0.02). rCBV and rPSF mean values were higher in tumoral tissue than in the contralateral area for high-grade gliomas (p < 0.01 and p < 0.05, respectively) and metastasis (p < 0.05 and p < 0.001, respectively). rCBV mean values of tumoral tissue were greater in high-grade than in low-grade gliomas (p < 0.05). rPSF mean levels of tumoral tissue were higher in metastasis than in low-grade gliomas (p < 0.02). These findings indicate that multi-parametric CTP mapping may contribute to differential diagnosis of solitary intra-axial brain tumors.

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Authors and Affiliations

  1. Neurosurgery Unit, Department of Neurosciences and Rahabilitation, Azienda Ospedaliera-Universitaria, Arcispedale S. Anna, Ferrara, Italy

    Enrico Fainardi & Francesco Di Biase

  2. Dipartimento di Neuroscienze e Riabilitazione, Unità Operativa di Neuroradiologia, Azienda Ospedaliera Universitaria, Corso della Giovecca 203, Arcispedale S. Anna, Ferrara, 44100, Italy

    Massimo Borrelli

Authors
  1. Enrico Fainardi
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  2. Francesco Di Biase
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  3. Massimo Borrelli
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  4. Andrea Saletti
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  5. Michele Cavallo
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  6. Silvio Sarubbo
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  7. Stefano Ceruti
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  8. Riccardo Tamarozzi
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  9. Arturo Chieregato
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Corresponding author

Correspondence to Enrico Fainardi .

Editor information

Editors and Affiliations

  1. Medical Research Center, PAN Warszawa, Ceglowska St. 80, Warszawa, 01-809, Poland

    Zbigniew Czernicki

  2. Klinikum Großhadern, Universitätsklinikum München, Marchioninistr. 15, München, 81377, Germany

    Alexander Baethmann

  3. Dept. Neurosurgery, Musashino Red Cross Hospital, Kyonan-cho 1-26-1, Musashino City, Tokyo, 180, Japan

    Umeo Ito

  4. School of Medicine, Nihon University, Oyaguchikami-machi 30-1 , Tokyo, 173-8610, Japan

    Yoichi Katayama

  5. Dept. Neuropathology, Medical Research Institute, Yushima 1-5-45, Tokyo, 113-8510, Japan

    Toshihiko Kuroiwa

  6. Dept. Neurosurgery, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE46BE, United Kingdom

    David Mendelow

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© 2010 Springer-Verlag/Wien

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Fainardi, E. et al. (2010). Potential Role of CT Perfusion Parameters in the Identification of Solitary Intra-axial Brain Tumor Grading. In: Czernicki, Z., Baethmann, A., Ito, U., Katayama, Y., Kuroiwa, T., Mendelow, D. (eds) Brain Edema XIV. Acta Neurochirurgica Supplementum, vol 106. Springer, Vienna. https://doi.org/10.1007/978-3-211-98811-4_53

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  • DOI: https://doi.org/10.1007/978-3-211-98811-4_53

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-98758-2

  • Online ISBN: 978-3-211-98811-4

  • eBook Packages: MedicineMedicine (R0)

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