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Decrease in nerve fibres in cerebral white matter in progressive subcortical vascular encephalopathy of binswanger type

An electron microscopic study

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Summary

To study white matter changes in the frontal lobes and to investigate the histopathological basis for the dementia in progressive subcortical vascular encephalopathy (PSVE), the frontal white matter was examined by electron microscopy in seven cases with PSVE, and compared with that in a control group and in cases with senile dementia of Alzheimer's type (SDAT). The number of nerve fibres per unit selected area of the white matter was significantly less in PSVE compared with that in the control group or in SDAT. Nerve fibres in PSVE had a tendency to have thinner myelin sheaths than in the control group or in SDAT, but the difference was not significant. The pallor of the frontal white matter in PSVE is mainly based on the loss of nerve fibres, and may be in part based on the thin myelin sheaths. The dementia in PSVE is probably related to the loss of nerve fibres in the cerebral white matter.

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References

  1. Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. Stroke 17:1084–1089

    Google Scholar 

  2. Awad IA, Johnson PC, Spetzler RF, Hodak JA (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations. Stroke 17:1090–1097

    Google Scholar 

  3. Binswanger O (1894) Die Abgrenzung der allgemeinen progressiven Paralyse. Berl Klin Wochenschr 31:1103–1105, 1137–1139, 1180–1186

    Google Scholar 

  4. DeReuck J, Crevits L, DeCoster W, Sieben G, Eecken H (1980) Pathogenesis of Binswanger chronic progressive subcortical encephalopathy. Neurology 30:920–928

    Google Scholar 

  5. Feigin I, Popoff N (1963) Neuropathological changes late in cerebral edema: the relationship to trauma, hypertensive disease and Binswanger's encephalopathy. J Neuropathol Exp Neurol 22:500–511

    Google Scholar 

  6. Haug H, Barmwater U, Eggers R, Fisher D, Kühl S, Sass NL (1983) Anatomical changes in aging brain: morphometric analysis of the human prosencephalon. In: Cervós-Navarro J, Sarkander HI (eds) Brain aging: neuropathology and neuropharmacology. Raven Press, New York, pp 1–12

    Google Scholar 

  7. Huang K, Wu L, Luo Y (1985) Binswanger's disease: progressive subcortical encephalopathy or multi-infarct dementia? Can J Neurol Sci 12:88–94

    Google Scholar 

  8. Jellinger K, Neumayer E (1964) Progressive subcorticale vasculäre Encephalopathie Binswanger. Eine klinisch-neuropathologische Studie. Arch Psychiatr Nervenkr 205:523–554

    Google Scholar 

  9. Okeda R (1973) Morphometrische Vergleichsuntersuchungen an Hirnarterien bei Binswangerscher Encephalopathie und Hochdruckencephalopathie. Acta Neuropathol (Berl) 26:23–43

    Google Scholar 

  10. Pakkenberg H (1966) The number of nerve cells in the cerebral cortex of man. J Comp Neurol 128:17–20

    Google Scholar 

  11. Raine GS, Traugott U (1985) Remyelination in chronic relapsing experimental allergic encephalomyelitis and multiple sclerosis. In: Adachi M, Hirano A, Aronson SM (eds) The pathology of the myelinated axon. Igaku-shoin, New York, pp 229–275

    Google Scholar 

  12. Strandgaard S, Olesen J, Skinhøj E, Lassen NA (1973) Autoregulation of brain circulation in severe arterial hypertension. Br Med J 1:507–510

    Google Scholar 

  13. Thomas DJ, DuBoulay GH, Marshall J, Pearson TC, Ross Russell RW, Symon L, Wetherley-Mein G, Zilkha E (1977) Effect of haematocrit on cerebral blood-flow in man. Lancet II:941–943

    Google Scholar 

  14. Tomonaga M, Yamanouchi H, Tohgi H, Kameyama M (1982) Clinicopathologic study of progressive subcortical vascular encephalopathy (Binswanger type) in the elderly. J Am Geriatr Soc 30:524–529

    Google Scholar 

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This work was supported in part by a Research Grant for Cardiovascular Diseases (A62-2) from the Ministry of Health and Welfare, Japan

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Yamanouchi, H., Sugiura, S. & Tomonaga, M. Decrease in nerve fibres in cerebral white matter in progressive subcortical vascular encephalopathy of binswanger type. J Neurol 236, 382–387 (1989). https://doi.org/10.1007/BF00314894

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  • DOI: https://doi.org/10.1007/BF00314894

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