Skip to main content
Log in

Multiple sclerosis and corpus callosum atrophy: Relationship of MRI findings to clinical data

  • Originals
  • Published:
Neuroradiology Aims and scope Submit manuscript

Summary

Among 110 patients (45 men, 65 women), aged 15 to 66, with clinical and/or biological diagnosis of multiple sclerosis (MS), severe to moderate corpus callosum (CC) atrophy was observed in 67 (60%) patients. Correlation between CC atrophy, brain atrophy, duration and severity of clinical symptoms, and high signal white matter areas, was carried out in 90 patients. Mean age was 46 years for those with severe CC atrophy, and 33 years for those without atrophy. Mean duration of the disease was 14 years in patients with severe atrophy, and 5 years in patients without atrophy. Severity of clinical symptoms is more pronounced in patients with severe CC atrophy. Numerous or large white matter high signal areas are observed in patients with severe CC atrophy on T2-weighted images. CC atrophy appears earlier than brain atrophy in the course of MS.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barkovich AJ, Norman D (1988) Anomalies of the corpus callosum: correlation with further anomalies of the brain. AJR 151: 171–179

    Google Scholar 

  2. Barnard RO, Triggs M (1974) Corpus callosum in multiple sclerosis. J Neurol Neurosurg Psychiatry 37:1259–1264

    Google Scholar 

  3. Davis RL, Robertson DM (1985) Textbook of neuropathology. Williams and Wilkins, Baltimore

    Google Scholar 

  4. Dietermann JL, Rumbach L, Beaujeux R, Roy C, Kastler B, Zöllner G, Marescaux C, Bourjat P, Wackenheim A (1988) IRM et sclérose en plaques. In: Lamarque JL, Mourou MY, Pujol J, Rouanet JP (eds) IRM corps entier. Axone, Montpellier

    Google Scholar 

  5. Kuhn MJ, Johnson KA, Davis KB (1988) Wallerian degeneration: evaluation with MR imaging. Radiology 168:199–202

    Google Scholar 

  6. Simon JH, Holtas SL, Schiffer RB, Rudick RA, Herndon RM, Kido DK, Utz R (1986) Corpus callosum and subcallosumperiventricular lesions in multiple sclerosis: detection with MR. Radiology 160:363–367

    Google Scholar 

  7. Simon JH, Schiffer RB, Rudick RA, Herndon RM (1987) Quantitative determination of MS-induced corpus callosum atrophy in vivo using MR imaging. AJNR 8:599–604

    Google Scholar 

  8. Warwick R, Williams PL (1973) Gray's anatomy. Saunders, Philadelphia

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dietemann, J.L., Beigelman, C., Rumbach, L. et al. Multiple sclerosis and corpus callosum atrophy: Relationship of MRI findings to clinical data. Neuroradiology 30, 478–480 (1988). https://doi.org/10.1007/BF00339686

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00339686

Key words

Navigation