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The value of computed tomography in patients with mucopolysaccharidosis

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Summary

Cranial computed tomography (CT) was performed on 11 cases of mucopolysaccharidosis (MPS) IVA (Morquio syndrome). Our results suggest that although the patients may have normal intelligence CT changes may be seen with increasing age. In two cases white matter low density was found and in a third there was gross dilatation of the ventricles, basal cisterns and subarachnoid space. Nine other patients with various types of mucopolysaccharidosis also had cranial CT performed and in general those types associated with mental retardation showed changes although there was an interesting exception involving a case of MPS IIIA who had a normal CT scan.

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Authors and Affiliations

  1. Department of Medical Genetics, Institute of Clinical Science, Belfast, Northern Ireland

    J. Nelson

  2. Department of Neuroradiology, Royal Victoria Hospital, Belfast, Northern Ireland

    F. S. Grebbell

  3. Locum Consultant Clinical Geneticist, Princess Margaret Hospital for Children, 6001, Perth, Western Australia

    J. Nelson

Authors
  1. J. Nelson
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  2. F. S. Grebbell
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Nelson, J., Grebbell, F.S. The value of computed tomography in patients with mucopolysaccharidosis. Neuroradiology 29, 544–549 (1987). https://doi.org/10.1007/BF00350438

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  • DOI: https://doi.org/10.1007/BF00350438

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