Summary
One hundred patients with CT-proven intracranial disease have been studied by magnetic resonance imaging (MRI) before and after intravenous injection with Gadolinium-DTPA (Gd-DTPA), in order to assess the role and clinical efficacy of Gd-DTPA. T2-weighted spin echo sequences, although sensitive to the detection of intracranial disease, in general fail to differentiate macroscopic tumour from oedema. Following Gd-DTPA, T1-weighted spin echo sequences in primary tumours demonstrated a variable degree of contrast enhancement unrelated to histological type. Small tumours, especially acoustic neuromas and meningiomas in the posterior fossa, were rendered more conspicuous. Optimum time for scanning was between five and 25 min following injection for all lesions except those adjacent to normal enhancing structures such as nasal/sinus mucosa and pituitary gland when delayed scans up to 45 min were necessary. No differences were observed between the 0.1 and 0.2 mmol/kg Gd-DTPA concentrations used and no complications attributable to Gd-DTPA were detected. Clinical advantages of Gd-DTPA include shorter scan times, macroscopic tumour/oedema separation and improved detection of certain tumours, particularly acoustic neuromas.
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Carr DH, Brown J, Bydder GM, Steiner RE, Weinmann H-J, Speck U, Hall AS, Young IR (1984) Gadolinium-DTPA as a contrast agent in MR imaging: initial clinical experience in 20 patients. AJR 143: 215–224
Felix R, Schörner W, Laniado M, Neindorf HP, Claussen C, Feigler W, Speck U, (1985) Brain tumours: MR imaging with Gadolinium-DTPA. Radiology 156: 681–688
Claussen C, Laniado M, Schörner W, Niendorf HP, Weinmann HJ, Fiegler W, Felix R (1985) Gadolinium-DTPA in MR imaging of glioblastomas and intracranial metastases. AJNR 6: 669–674
Graif M, Bydder GM, Steiner RE, Niendorf P, Thomas DGT, Young IR (1985) Contrast-enhanced MR imaging of malignant brain tumours. AJNR 6: 855–862
Weinmann HJ, Laniado M, Mützel W (1984) Pharmacokinetics of Gd-DTPA/dimeglumine after intravenous injection into healthy volunteers. Physiol Chem Phys Med NMR 16 (12): 167–172
Laniado M, Weinmann HJ, Schörner W, Felix R, Speck U (1984) First use of Gd-DTPA/Dimeglumine in man. Physiol Chem Phys Med NMR 16: 157–165
Carr DH, Brown J, Bydder GM, Weinmann HJ, Speck V, Thomas DJ, Young IR (1984) Intravenous chelated Gadolinium as a contrast agent in NMR imaging of cerebral tumours. Lancet I: 484–486
Bydder GM, Steiner RE, Young IR, Hall AS, Thomas DJ, Marshall J, Pallis CA, Legg NJ (1982) Clinical NMR imaging of brain: 140 cases. AJR 139: 215–236
Brant-Zawadzki M, Norman D, Newton TH, Kelly WM, Kjos B, Mills CM, Dillon W, Sobel D, Crookes LE (1984) Magnetic resonance of the brain: the optimal screening technique. Radiology 152: 71–77
Komiyama M, Yagura H, Baba M, Yasui T, Hakuba A, Nishimura S, Inoue Y (1987) MR imaging: possibility of tissue characterisation of brain tumours using T1 and T2 values. AJNR 8: 65–70
Kilgore DP, Breger RK, Daniels DL, Pojunas KW, Williams AL, Haughton VM (1986) Cranial tissues: normal MR appearance after intravenous injection of Gd-DTPA. Radiology 160: 757–761
Lunsford LD, Martinez AJ, Latchaw RE (1987) Magnetic resonance imaging does not define tumour boundaries. Acta Radiol [Suppl] 369: 154–156
Virapongse C, Mancuso A, Quisling R (1986) Human brain infarcts: Gd-DTPA-enhanced MR imaging. Radiology 161: 785–794
Bydder GM, Kingsley DPE, Brown J, Niendorf HP, Young IR (1985) MR imaging of meningioma including studies with and without Gadolinium-DTPA. JCAT 9 (4): 690–697
Haughton VM, Rimm AA, Sobocinski KA, Papke RA, Daniels DL, Williams AL, Lynch R, Levine R (1986) A blinded clinical comparison of MR imaging and CT in neuroradiology. Radiology 160: 751–755
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Stack, J.P., Antoun, N.M., Jenkins, J.P.R. et al. Gadolinium-DTPA as a contrast agent in magnetic resonance imaging of the brain. Neuroradiology 30, 145–154 (1988). https://doi.org/10.1007/BF00395616
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DOI: https://doi.org/10.1007/BF00395616