Summary
Owing to their shape, accurately calibrated microspheres appear to be very suitable material for distal embolization. Moreover, the biocompatible (D, L) polyactide (PLA) microspheres possess two other valuable advantages: easy adjustment of their biodegradation rate, and incorporation of chemotherapeutic agents during their production. The authors describe the preparation of these (D, L) PLA microspheres and their clinical applications as a preliminary step to arterial chemoembolization.
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References
Madoule PH, Trampont PH, Roche A (1984) Chemoembolization: principles and perspectives. J Microencapsul 1: 21–25
Wright KC, Anderson JH, Gianturco C, Wallace S, Chuang VP (1982) Partial splenic embolization using polyvinyl alcohol foam, dextran, polystyrene, or silicone: an experimental study in dogs. Radiology 142: 351–354
Dion JE, Rankin RN, Vinuela F, Fox AJ, Wallace AC, Mervart M (1986) Dextran microsphere embolization: experimental and clinical experience with radiologic — pathologic correlation. Radiology 160: 717–721
Kato T, Nemoto R, Mori H, Kumagai I (1980) Sustained-release properties of microencapsulated mitomycin C with ethylcellulose infused into the renal artery of the dog. Cancer 46: 14–21
Dakhil S, Ensminger W, Cho K, Niederhuber J, Doan K, Wheeler R (1981) Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer 50: 631–635
Willmott H, Cummings J, Stuart JFB, Florence AT (1984) Adriamycin-loaded albumin microspheres: preparation, in vivo distribution and release in the rat. Biopharm Drug Dispos 6: 91–104
Fujimoto S, Miazaki M, Endoh F, Takahashi D, Okvi K, Morimoto Y (1985) Biodegradable mitomycin C microspheres given intra-arterially for inoperable hepatic cancer with particular reference to a comparaison with continuous infusion of mitomycine C and 5-fluorouracil. Cancer 56: 2404–2410
Okamoto Y, Konno A, Togawa K, Kato T, Tamakawa Y, Amamo Y (1986) Arterial chemoembolization with cisplatin microcapsules. Br J Cancer 53: 369–375
Repa I, Moradian GP, Dehner LP et al. (1989) Mortalities associated with use of a commercial suspension of polyvinyl alcohol. Radiology 170: 395–399
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Flandroy, P., Grandfils, C., Collignon, J. et al. (D, L) Polylactide microspheres as embolic agent. Neuroradiology 32, 311–315 (1990). https://doi.org/10.1007/BF00593051
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DOI: https://doi.org/10.1007/BF00593051