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MRI and SPECT findings in amyotrophic lateral sclerosis

Demonstration of upper motor neurone involvement by clinical neuroimaging

  • Diagnostic Neuroradiology
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Summary

MRI was performed in 21 patients and single photon emission computed tomography (SPECT) withN-isopropyl-p-123I iodoamphetamine in 16 patients, to visualize upper motor neurone lesions in amyotrophic lateral sclerosis. T2-weighted MRI revealed high signal along the course of the pyramidal tract in the internal capsule and cerebral peduncle in 4 of 21 patients. SPECT images were normal in 4 patients, but uptake was reduced in the cerebral cortex that includes the motor area in 11.

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Udaka, F., Sawada, H., Seriu, N. et al. MRI and SPECT findings in amyotrophic lateral sclerosis. Neuroradiology 34, 389–393 (1992). https://doi.org/10.1007/BF00596496

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  • DOI: https://doi.org/10.1007/BF00596496

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