Skip to main content
SpringerLink
Log in

Studies on vascular permeability in peripheral nerves

I. Distribution of circulating fluorescent serum albumin in normal, crushed and sectioned rat sciatic nerve

  • Original Investigations
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Abdou, I. A., andH. Tarver: Plasma protein. 1. Loss from circulation and catabolism to carbon dioxide. J. biol. Chem.190, 769–780 (1951).

    Google Scholar 

  • Adams, W. E.: The blood supply of nerves. 1. Historical review. J. Anat. (Lond.)76, 323–341 (1942).

    Google Scholar 

  • Abell, R. G.: Quantitative studies of the rate of passage of nitrogenous substances through the walls of growing and differentiating mammalian blood capillaries. Collecting Net.14, 213–214 (1939).

    Google Scholar 

  • —: The permeability of blood capillary sprouts and newly formed blood capillaries as compared to that of older capillaries. Amer. J. Physiol.147, 237–241 (1946).

    Google Scholar 

  • Abercrombie, M., andM. L. Johnson: The effect of reinnervation on collagen formation in degenerating sciatic nerves of rabbits. J. Neurol. Neurosurg. Psychiat.10, 89–92 (1947).

    Google Scholar 

  • Andén, N.-E., andY. Olsson: 5-Hydroxytryptamine in normal and sectioned sciatic nerve of the rat. To be published.

  • Bateman, J. E.: Trauma to nerves in limbs. Philadelphia and London: W. B. Saunders Co. 1962.

    Google Scholar 

  • Blackwood, W., andW. Holmes: Histopathology of nerve injury. In: Peripheral nerve injuries, edit. byH. J. Seddon, pp. 88–105. London: Her Majesty's Stationary Office 1954.

    Google Scholar 

  • Blümcke, S.: Zur Morphologie und Genese des Leitgewebes peripherer Nervenregenerate. 1. Lichtmikroskopische Untersuchungen an frühen Regenerationsstadien. Zbl. allg. Path. path. Anat.104, 228–241 (1962).

    Google Scholar 

  • Campbell, R. M., D. P. Cuthbertson, C. M. Matthews, andA. S. Mc Fairlane: Behaviour of14C- and131J-labelled plasma proteins in the rat. J. appl. Radiat. Isotop.1, 66–84 (1956).

    Google Scholar 

  • Crescitelli, F.: Nerve sheath as a barrier to the action of certain substances. Amer. J. Physiol.166, 229–240 (1951).

    Google Scholar 

  • —, andT. A. Geissman: Certain effects of antihistamines and related compounds on frog nerve fibers. Amer. J. Physiol.164, 509–519 (1951).

    Google Scholar 

  • Denny-Brown, D., andC. Brenner: Lesion in peripheral nerves resulting from compression by spring clip. Arch. Neurol. Psychiat. (Chic.)52, 1–19 (1944a).

    Google Scholar 

  • ——: The effect of percussion of nerve. J. Neurol. Neurosurg. Psychiat.7, 76–95 (1944b).

    Google Scholar 

  • Dihlmann, W., G. Liebaldt u.W. Undeutsch: Die Kapillarsprossung als Regenerationsprinzip bei örtlichen Strahlenschäden. Strahlentherapie114, 552–564 (1961).

    Google Scholar 

  • Edshage, S.: Peripheral nerve suture. A technique for improved intraneural topography and evaluation of some suture materials. Acta chir. scand. Suppl. 331 (1964).

  • Emiroglu, F.: The permeability of the perineural nerve sheaths in frogs. Arch. int. Physiol.63, 161–180 (1955).

    Google Scholar 

  • Enerbäck, L., Y. Olsson, andP. Sourander: Mast cell changes following nerve sectioning p. 35–36. Proc. XIV Congr. Path. Microbiol. Oslo: Universitetsforlaget 1964.

    Google Scholar 

  • ———: Mast cells in normal and sectioned peripheral nerve. Z. Zellforsch.66, 596–608 (1965).

    Google Scholar 

  • Euler, U. S. v.: Histamine as a specific constituent of certain autonomic fibres. Acta physiol. scand.19, 85–93 (1949).

    Google Scholar 

  • —: Histamine in nerves. In: CIBA Found. Symp. on Histamine, pp. 264–269. London: J. A. Churchill Ltd. 1960.

    Google Scholar 

  • —, andA. Åström: Liberation of histamine and sympathin by stimulation of isolated splenic nerves from cattle. Acta physiol. scand.16, 97–107 (1948).

    Google Scholar 

  • Everett, N. B., andB. I. Simmons: Measurement and radioautographic localization of albumin in rat tissues after intravenous administration. Circulat. Res.6, 307–313 (1958).

    Google Scholar 

  • Feng, T. P., andR. W. Gerard: Mechanism of nerve asphyxiation; with a note on the nerve sheath as a diffusion barrier. Proc. Soc. exp. Biol. (N.Y.)27, 1073–1076 (1930).

    Google Scholar 

  • —, andY. M. Lieu: The connective tissue sheath of a nerve as effective diffusion barrier. J. cell. comp. Physiol.34, 1–16 (1949).

    Google Scholar 

  • Gamble, H. J.: Comparative electron-microscopic observations on the connective tissues of a peripheral nerve and a spinal nerve root in the rat. J. Anat. (Lond.)98, 17–25 (1964).

    Google Scholar 

  • Gitlin, D., andC. A. Janeway: Some isotopic studies on the distribution and metabolism of plasma proteins. Advanc. biol. med. Phys.7, 249–293 (1960).

    Google Scholar 

  • Green, J. P.: Histamine and the nervous system. Fed. Proc.23, 1095–1102 (1964).

    Google Scholar 

  • Greenfield's Neuropathology, 2nd ed., edit. byW. Blackwood, H. Mc Menemy, A. Meyer, R. W. Norman, andD. S. Russel. London: Edward Arnold Ltd. 1963.

    Google Scholar 

  • Humphrey, J. H., A. Neuberger, andD. Perkins: Observations on the presence of plasma proteins in skin and tendon. Biochem. J.66, 390–399 (1957).

    Google Scholar 

  • Huxley, A. F., andR. Stämpfli: Effect of potassium and sodium on resting and action potential of single myelinated nerve fibres. J. Physiol. (Lond.)112, 496–508 (1951).

    Google Scholar 

  • Johnson, A. C., A. R. McNabb, andR. J. Rossiter: Chemical studies of peripheral nerve during Wallerian degeneration. Biochem. J.45, 500–508 (1949).

    Google Scholar 

  • ———: Chemistry of Wallerian degeneration. A review of recent studies. Arch. Neurol. Psychiat. (Chic.)64, 105–121 (1950).

    Google Scholar 

  • Key, A., u.G. Retizus: Studien in der Anatomie des Nervensystemes. Arch. mikr. Anat.9, 308–386 (1873).

    Google Scholar 

  • ——: Studien in der Anatomie des Nervensystemes und des Bindegewebes. Stockholm: Samson & Wallin 1876.

    Google Scholar 

  • Klatzo, I., J. Miquel, C. Tobias, andW. Haymaker: Effects of alpha-particle radiation on the rat brain, including vascular permeability and glycogen studies. J. Neuropath. exp. Neurol.20, 459–483 (1961).

    Google Scholar 

  • —— andR. Otenasek: The application of fluorescein labelled serum proteins (FLSP) to the study of vascular permeability in the brain. Acta neuropath. (Berl.)2, 144–160 (1962).

    Google Scholar 

  • —, andO. Steinwall: Observation on cerebrospinal fluid pathways and behaviour of the bloodbrain barrier in sharks. Acta neuropath. (Berl.)5, 161–175 (1965).

    Google Scholar 

  • —,W. Wisniewski, andD. Smith: Observations on penetration of serum proteins into the central nervous system. Progr. Brain Res.15, 73–88 (1965).

    Google Scholar 

  • Krnjevic, K.: Some observations on perfused frog sciatic nerves. J. Physiol. (Lond.)123, 338–386 (1954a).

    Google Scholar 

  • —: The connective tissue sheath of the frog sciatic nerve. Quart. J. exp. Physiol.39, 55–72 (1954b).

    Google Scholar 

  • Kwiatkowski, H.: Histamine in nervous tissue. J. Physiol. (Lond.)102, 32–41 (1943).

    Google Scholar 

  • Lehmann, H.-J.: The epineurium as a diffusion barrier. Nature (Lond.)102, 1045 (1953).

    Google Scholar 

  • —: Über Struktur und Funktion der perineuralen Diffusionsbarriere. Z. Zellforsch.46, 232–241 (1957).

    Google Scholar 

  • Lundberg, A.: Electrotonus in frog spinal roots and sciatic trunk. Acta physiol. scand.23, 234–262 (1951).

    Google Scholar 

  • Majno, G.: Mechanisms of abnormal vascular permeability in acute inflammation. In: Injury, inflammation and immunity, edit. byL. Thomas, J. W. Uhr, andL. Grant, pp. 58–93. Baltimore: The Williams & Wilkins Co. 1964.

    Google Scholar 

  • —, andM. L. Karnowsky: A biochemical and morphological study of myelination and demyelination. II. Lipogenesis in vitro by rat nerves following transection. J. exp. Med.108, 197–214 (1958).

    Google Scholar 

  • ——: A biochemical and morphological study of myelination and demyelination. III. Effect of an organo-phosphorous compound (Mipafox) on the biosynthesis of lipid by nervous tissue of rats and hens. J. Neurochem.8, 1–16 (1961).

    Google Scholar 

  • Mancini, R. E.: Connective tissue and serum proteins. Int. Rev. Cytol.14, 193–222 (1963).

    Google Scholar 

  • —,O. Vilar, B. Alvarez, andA. C. Seigner: Extravascular and intratubular diffusion of serum proteins in the rat testis. J. Histochem. Cytochem.13, 376–385 (1965).

    Google Scholar 

  • —,J. M. Dellacha, O. W. Davidson, A. Castro, andB. Alvarez: Extravascular distribution of fluorescent albumin, globulin and fibrinogen in connective tissue structures. J. Histochem. Cytochem.10, 194–203 (1962).

    Google Scholar 

  • —,O. Vilar, M. E. Péréz del Cerro, andJ. C. Lavieri: A histological, histochemical and electron-microscopic study of stromal connective tissue of human testis. Acta physiol. lat.-amer.14, 382–391 (1964).

    Google Scholar 

  • —,O. Vilar, C. Gomez, J. M. Dellacha, O. W. Davidson, andA. Castro: Histological study of distribution of fluorescent serum proteins in connective tissue. J. Histochem. Cytochem.9, 356–361 (1961).

    Google Scholar 

  • ——,J. J. Heinrich, O. W. Davidson, andB. Alvarez: Transference of circulating labelled serum proteins to the follicle of the rat ovary. J. Histochem. Cytochem.11, 80–88 (1963).

    Google Scholar 

  • Manell, W. A.: Wallerian degeneration in the rat. A chemical study. Canad. J. med. Sci.30, 173–179 (1952).

    Google Scholar 

  • Martin, K. H.: Untersuchungen an gefriertrockenen Nerven über die perineurale Diffusions-barriere. Z. Zellforsch.64, 404–428 (1964).

    Google Scholar 

  • May, M. R. M.: Etudes microchimiques sur le systéme nerveux. III. L'eau et les combinasions phosphorées du nerf au cours de sa dégénérescence. Bull. Soc. Chim. Biol. (Paris)12, 934–953 (1930).

    Google Scholar 

  • Mott, F. W., andW. D. Halliburton: The chemistry of nerve degeneration. Phil. Trans. B194, 437–466 (1901a).

    Google Scholar 

  • ——: The chemistry of nerve-degeneration. Lancet1, 1077–1078 (1901b).

    Google Scholar 

  • Kairn, R. C.: Fluorescent protein tracing. Edinburgh & London: E. & S. Livingstone Ltd 2nd ed 1964.

    Google Scholar 

  • Niklas, A., u.W. Maurer: Über die Neubildung einzelner, getrennter Serum-Eiweiß-Fraktionen nach oraler Gabe von S35-1-Methionin an Ratten. Biochem. Z.323, 89–103 (1952).

    Google Scholar 

  • Oeff, K.: Umsatz von radioaktiven Serumeiweißfraktionen. II. Versuche an normalen Ratten. Z. ges. exp. Med.123, 309–314 (1954).

    Google Scholar 

  • Olsson, Y.: Storage of monoamines in mast cells of normal and sectioned peripheral nerve. Z Zellforsch.68, 255–265 (1965).

    Google Scholar 

  • Olsson, Y.: The effect of the histamine liberator, Compound 48/80 on mast cells in normal peripheral nerve. Acta path. microbiol. scand. (in press) (1966a).

  • Olsson, Y.: Studies on vascular permeability in peripheral nerves. 2. Distribution of circulating fluorescent serum albumin in rat sciatic nerve after local injections of histamine, 5-hydroxytryptamine and Compound 48/80. To be published 1966b.

  • Rexed, B., andU. S. v. Euler: The presence of histamine and noradrenaline in nerves as related to their content of myelinated and unmyelinated fibres. Acta physiol. scand.26, 61–65 (1951).

    Google Scholar 

  • Richards, R. L.: Ischemic lesions of peripheral nerves: A review. J. Neurol. Neurosurg. Psychiat.14, 76–87 (1951).

    Google Scholar 

  • Rossiter, R. J.: The chemistry of Wallerian degeneration. In: Chemical pathology of the nervous system, pp. 207–227. Ed. byJ. Folch-Pr. Oxford: Pergamon Press 1961.

    Google Scholar 

  • Röhlich, P., u.A. Knoop: Elektronenmikroskopische Untersuchungen an den Hüllen des N. ischiadicus der Ratte. Z. Zellforsch.53, 299–312 (1961).

    Google Scholar 

  • —, andM. Weiss: Studies on the histology and permeability of the peripheral nervous barrier. Acta morph. (Basel)5, 335–347 (1955).

    Google Scholar 

  • Schoefl, Gutta, I.: Studies on inflammation. III. Growing capillaries: Their structure and permeability. Virchows Arch. path. Anat.337, 97–141 (1963).

    Google Scholar 

  • Shanthaveerappa, T. R., andG. H. Bourne: A perineural epithelium. J. Cell Biol.13, 343–346 (1962a).

    Google Scholar 

  • ——: The perineural epithelium: A metabolic active, continuous, protoplasmic cell barrier surrounding peripheral nerve fasciculi. J. Anat. (Lond.)96, 527–537 (1962b).

    Google Scholar 

  • ——: The perineural epithelium: Nature and significance. Nature (Lond.)199, 577–579 (1963).

    Google Scholar 

  • ——: The perineural epithelium of symphathetic nerves and ganglion and its relation to the pia-arachnoid mater of the central nervous system and perineural epithelium of peripheral nerves. Z. Zellforsch.61, 742–753 (1964).

    Google Scholar 

  • —,J. Hope, andG. H. Bourne: Electron microscopic demonstration of perineural epithelium of sciatic nerve. Acta anat. (Basel)52, 193–201 (1963).

    Google Scholar 

  • Spector, W. G.: Substances which affect capillary permeability. Pharmacol. Rev.10, 475–505 (1958).

    Google Scholar 

  • —, andD. A. Willoghby: The inflammatory response. Bact. Rev.27, 117–154 (1963).

    Google Scholar 

  • ——: Vasoactive amines in acute inflammation. Trans. N.Y. Acad. Sci.116, 839–845 (1964).

    Google Scholar 

  • ——: Chemical mediators II. In: The inflammatory response, pp. 427–448. Ed. byB. W. Zweifach, L. Grant, andR. T. McCluscey. New York and London: Academic Press 1965.

    Google Scholar 

  • Steinwall, O., andI. Klatzo: Double tracer methods in studies on blood-brain barrier dysfunction and brain edema. Proc. 17th Congr. Scand. Neurol., Göteborg 1964. Acta neurol. scand. 41, suppl. 13, R31/1-R31/5 1965.

    Google Scholar 

  • Sterling, K.: The turnover rat of serum albumin in man as measured by J131-tagged albumin. J. clin. Invest.30, 1228–1237 (1951).

    Google Scholar 

  • Streicher, E., H. Wisniewski, andI. Klatzo: Resistance of immature brain to experimental cerebral edema. Neurology (Minneap.)15, 833–836 (1965).

    Google Scholar 

  • Sunderland, S.: Blood supply of the nerves of the upper limb in man. Arch. Neurol. Psychiat. (Chic.)53, 91–115 (1945).

    Google Scholar 

  • Thomas, P. K.: The connective tissue of peripheral nerve: An electron microscopic study. J. Anat. (Lond.)97, 35–44 (1963).

    Google Scholar 

  • —: The cellular response to nerve injury 1. The cellular outgrowth from the distal stump of transected nerve. J. Anat. (Lond.)100, 287–303 (1966).

    Google Scholar 

  • Torp, A.: Histamine and mast cells in nerves. Med. exp. (Basel)4, 180–182 (1961).

    Google Scholar 

  • Uvnäs, B.: Release processes in mast cells and their activation by injury. Trans. N.Y. Acad. Sci.116, 880–890 (1964).

    Google Scholar 

  • Waggener, J. D., S. M. Bunn, andJ. Beggs: The diffusion of ferritin within the peripheral nerve sheath: An electron microscopy study. J. Neuropath. exp. Neurol.24, 430–443 (1965).

    Google Scholar 

  • Waksman, B. H.: Experimental study of diphteric polyneuritis in the rabbit and guinea pig. III. The blood-nerve barrier in the rabbit. J. Neuropath. exp. Neurol.20, 35–77 (1961).

    Google Scholar 

  • Weisl, H., andG. V. Osborne: The pathological changes in rats' nerves subject to moderate compression. J. Bone Jt Surg. B46, 297–306 (1964).

    Google Scholar 

  • Weiss, M., andP. Röhlich: Significance of the interstice of the peripheral nerve. Acta morph. (Basel)4, 309–318 (1954).

    Google Scholar 

  • Weiss, P.: Endoneurial edema in constricted nerve. Anat. Rec.86, 491–522 (1943).

    Google Scholar 

  • —, andH. Davis: Pressure block in nerves provided with aterial sleeves. J. Neurophysiol.6, 269–286 (1943).

    Google Scholar 

  • —,H. Wang, A. C. Taylor, andM. V. Edss: Proximo-distal fluid convection in the endoneurial spaces of peripheral nerves, demonstrated by colour and radioactive (isotope) tracers. Amer. J. Physiol.143, 521–540 (1945).

    Google Scholar 

  • Werle, E.: Histamine in nerves. In CIBA Found. Symp. on Histamine, pp. 264–269. London: J. A. Churchill Ltd. 1956.

    Google Scholar 

  • —, u.A. Schauer: Histamine in Nerven. IV. Z. ges. exp. Med.127, 16–21 (1956).

    Google Scholar 

  • —, u.G. Weicken: Über das Vorkommen von Histaminen in Nerven. Biochem. Z.319, 457–462 (1949).

    Google Scholar 

  • West, G. B.: Histamine in nervous tissue. In: Metabolism of the nervous system. Proc. 2nd Int. Symp. Neurochem. held in Aarhus, Denmark, in July 1956, pp. 578–581. Ed.D. Richter. London, New York, Paris, Los Angeles: Pergamon Press 1957a.

    Google Scholar 

  • —: 5-hydroxytryptamine, tissue mast cells and skin oedema. Int. Arch. Allergy10, 257–275 (1957b).

    Google Scholar 

  • Wilhelm, D. L.: The mediation of increased vascular permeability in inflammation. Pharmacol. Rev.14, 251–280 (1962).

    Google Scholar 

  • —: Chemical mediators. I. In: The inflammatory process, pp. 389–425. Ed. byB. W. Zweifach, L. Grant, andR. T. McCluskey. New York and London: Academic Press 1965.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Neuropathological Laboratory, Department of Pathology I, University of Göteborg, Ehrenströmsgatan 1, Göteborg, Sweden

    Yngve Olsson

Authors
  1. Yngve Olsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Olsson, Y. Studies on vascular permeability in peripheral nerves. Acta Neuropathol 7, 1–15 (1966). https://doi.org/10.1007/BF00686605

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00686605

Keywords

Search

Navigation