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The use of radiation in the management of spinal metastases

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References

  1. Leibel A, Sheline E: Tolerance of the brain and spinal cord to conventional irradiation. In: Gutin PH (ed) Radiation Injury to the Nervous System. 1991, p 239–256

  2. Fein DA, Marcus RB, Jr: Lhermitte's sign: incidence and treatment variables influencing risk after irradiation of the cervical spinal cord. Int J Rad Biol Phy 27(5): 1029–1033, 1993

    Google Scholar 

  3. Combes PF, Daly N: Late progressive radiation myelopathies. A study of 27 cases. J Radiol Electrol Med Nucl 57(11): 815–825, 1975

    Google Scholar 

  4. Lambert PW, Davis RL: Delayed effects of radiation on the human central nervous system. Neurology 14: 912–917, 1964

    Google Scholar 

  5. Lamy C, Mas JL: Post radiation lower motor neuron syndrome presenting as monomelic amytrophy. J of Neurology, Neurosurgery + Psychiatry 54(7): 648–649, 1991

    Google Scholar 

  6. Schulthesis T, Stephens C: The pathogenesis of radiation myelopathy: widening the circle. Int J Radiation Oncology Biol Phys 23: 1089–1091, 1992

    Google Scholar 

  7. Chiang C: Radiation effects on C.N.S. Diss Abstr Int (B): 1235, 1992

  8. Feldmeier JJ: Hyperbaric oxygen as prophylaxis or treatment for radiation myelndersea & Hyperbaric Medicine 20(3): 249–255, 1993

    Google Scholar 

  9. Geyer JR, Taylor EM: Radiation, methotrexate, and white matter necrosis: laboratory evidence for neural radioprotection with preradiation methotrexate. Int J Radiation Oncology Biol Phys 15(2): 373–375, 1988

    Google Scholar 

  10. Gutin PH, McDermott MW: Polyamine accumulation and vasogenic oedema in the genesis of late delayed radiation injury of the central nervous system. Acta Neurochirurgica-Supplentum 51: 372–374, 1990

    Google Scholar 

  11. Hornsey S. Myers R: The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs. Int J Radiation Oncology Biol Phys 18(6): 1437–1442, 1990

    Google Scholar 

  12. Rubin P Whitaker JN: Myelin basic protein and magnetic resonance imaging for diagnosing radiation myelopathy. Int J Radiation Oncology Biol Phys 15(6): 1371–1381, 1988

    Google Scholar 

  13. Baddley H, Bekiaridis P: Magnetic resonance imaging in the diagnosis of radiation myelitis. Radiology and Oncology meeting, U.K. p45, 1991

  14. de Scisciolo G, Bartelli M: Long term nervous system damage from radiation of the spinal cord: an electrophysiological study. J of Neurology 238(1): 9–15, 1991

    Google Scholar 

  15. Pallis CA, Louis S: Radiation Myelopathy Brain 84: 460–479, 1961

    Google Scholar 

  16. Boden G: Radiation myelitis of the cervical cord. Brit J Radiol 4: 464–469, 1948

    Google Scholar 

  17. Atkins HL, Tretter P: Time dose considerations in radiation myelopathy. Acta Radiol 5: 78–94, 1966

    Google Scholar 

  18. Phillips TL, Buchke F: Radiation tolerance of the thoracic spinal cord. Am J Roentgen 105: 675–664, 1969

    Google Scholar 

  19. Emami B, Lyman J: Tolerance of normal tissue to therapeutic irradiation. Int J Radiation Oncology Biol Phys 21(1): 109–122, 1991

    Google Scholar 

  20. Schulthesiss T: Spinal cord radiation ‘tolerance’: doctrine versus data. Int J Radiation Oncology Biol Phys 19: 219–221, 1990

    Google Scholar 

  21. Jeremic B, Djuric L: Incidence of radiation myelitis of the spinal cord at doses of 5500 cGy or greater. Cancer 68: 2138–2141, 1991

    PubMed  Google Scholar 

  22. McCuniff, Liang M: Radiation tolerance of the cervical spinal cord. Int J Radiation Oncology Biol Phys 16: 675–678, 1988

    Google Scholar 

  23. Marcus R, Million R: The incidence of myelitis after irradiation of the cervical spinal cord. Int J Radiation Oncology Biol Phys 19: 3–8, 1990

    Google Scholar 

  24. Crellin RP, Macmillan CH: Multiple fractions daily for head and neck cancer: spinal cord effects and other late results. Clinical Oncology 5(3): 139–142, 1993

    PubMed  Google Scholar 

  25. Van der Schuren E, Landuyt W: From 2 Gy to 1 Gy per fraction: sparing effect in rat spinal cord? Int J Radiation Oncology Biol Phys 14(2): 297–300, 1988

    Google Scholar 

  26. Lavey RS, Johnson AK: The effect of hyperfractionation on spinal cord response to radiation. Int J Radiation Oncology Biol Phys 24(4): 681–686, 1992

    Google Scholar 

  27. Wong CS, Minkin S: Linear-quadratic model underestimates sparing effect of small doses per fraction in rat spinal cord. Radiotherapy & Oncology 23(3): 176–184, 1992

    Google Scholar 

  28. Ang KK, Jiang GL: Impact of spinal cord repair kinetics on the practice of altered fractionation schedules. Radiotherapy & Oncology 25(4): 287–294, 1992

    Google Scholar 

  29. Morgan DA, Berridge JK: Radiotherapy with three small fractions daily short interfraction interval-late effects. British J Cancer 66(suppl XXV11): 14, 1992

    Google Scholar 

  30. Hopewell JW, Morris A: The influence of field size on late tolerance of the rat spinal cord to single doses of X-rays. Br J Radiol 60: 1099–1108, 1987

    PubMed  Google Scholar 

  31. Abbatucci JS, Delozier T: Radiation myelopathy of the spinal cord. Time, dose and volume factors. Int J Radiation Biol Phys 4: 239–248, 1979

    Google Scholar 

  32. Wara WM, Phillips TL: Radiation tolerance of the spinal cord. Cancer 35: 1558–1562, 1975

    PubMed  Google Scholar 

  33. Gillian LA: Veins of the spinal cord. Neurology 20: 860–868, 1970

    PubMed  Google Scholar 

  34. Wong CS, Minkin S: Re-irradiation tolerance of rat spinal cord to fractionated X-ray doses. Radiotherapy & Oncology 28: 197–202, 1993

    Google Scholar 

  35. van der Kogel AJ: Re-treatment of the spinal cord. Int J Radiation Oncology Biol Phys 26(4): 715–717, 1993

    Google Scholar 

  36. Ang KK, Price RE: The tolerance of primate spinal cord to re-irradiation. Int J Radiation Oncology Biol Phys 25(3): 459–464, 1993

    Google Scholar 

  37. Mason KA, Withers HR: Late effects of radiation on the lumbar spinal cord of guinea pigs: re-treatment tolerance

  38. Tan BC, Khor TH: Radiation myelitis in carcinoma of the nasopharynx. Clin Radiol 20: 329–331, 1969

    PubMed  Google Scholar 

  39. Magrini SM, Biti GP: Neurological damage in patients irradiated twice on the spinal cord: a morphological and electrophysiological study. Radiotherapy & Oncology 17(3): 209–218, 1990

    Google Scholar 

  40. Ruifrok AK, van der Kogel AJ: The effect of intraspinal cytosine arbinoside on the re-irradiation tolerance of the cervical spinal cord of young and adult rats. European J Cancer 29A(12): 1766–1770, 1993

    Google Scholar 

  41. Dische S, Martin WMC: Radiation myelopathy in patients treated for carcinoma of the bronchus using 6 fraction regime of radiotherapy. Int J Radiotherapy Oncology Biol Phys 54: 29–35, 1981

    Google Scholar 

  42. Hatlevol R, Host H: Myelopathy following radiotherapy of bronchial carcinoma with large single fractions a retrospective review. Int J Radiotherapy Oncology Biol Phys 9: 41–44, 1983

    Google Scholar 

  43. Asscher AW, Anson SG: Arterial hypertension and irradiation to the nervous system. Lancet 11: 1343–1346, 1962

    Google Scholar 

  44. Rao JS, Kano S: Decreased levels of glial-derived nexin/protease nexin 1 in irradiated rat cordin vivo. Biochem & Biophy Research Comm 195(2): 853–858, 1993

    Google Scholar 

  45. Rao JS, Kano S: The role of PAI1 in the pathogenesis of delayed radiation damage of the spinal cord in rats. Proc Annu Meet Am Assoc Cancer Res 33: A460, 1992

    Google Scholar 

  46. Wong CS, Van Dyk J: Myelopathy following hyperfractionated accelerated radiotherapy for anaplastic thyroid carcinoma. Radiother & Oncol 20(1): 3–9, 1991

    Google Scholar 

  47. Willis RA: The spread of tumors in the human body ed.3 Butterwortts 1973

  48. Perrin RG, McBroom RJ: Metastatic tumors of the cervical spine. In: Black N (ed) Clinical Neurosurg. Williams & Wilkins. 101/37: 740–755, 1991

  49. Sunderson N, Digiaconto GV: Treatment of neoplastic spinal cord compression results of prospective study. Neurosurg 29: 645–650, 1991

    PubMed  Google Scholar 

  50. Lenz M, Freid JR: Metastases to the skeleton, brain and spinal cord from cancer of the breast and the effect of radiotherapy. Ann Surg 39: 278–293, 1931

    Google Scholar 

  51. Klein SL, San Ford RA: Pediatric spinal epidural metastases. J Neurosurg 74: 70–75, 1991

    PubMed  Google Scholar 

  52. Raffel C, Neave V: Treatment of spinal cord compression by epidural malignancy in childhood. Neurosurg 28: 349–352, 1991

    Google Scholar 

  53. Livingston KE, Perin RG: Neurosurgical management of spinal metastases. Neurosurg 49: 839–843, 1978

    Google Scholar 

  54. Hoskin PJ: Scientific & clinical aspects of radiotherapy in the relief of bone pain. Cancer Surv 7: 69–86, 1980

    Google Scholar 

  55. Arguella F, Baggs RB: Pathogenesis of vertebral metastases & epidural spinal cord compression. Cancer 65: 98, 1990

    PubMed  Google Scholar 

  56. Haddad C, Thaell JF: Lymphoma of the spinal extradural space. Cancer 38: 1862, 1976

    PubMed  Google Scholar 

  57. Gilbert W, Kim: Epidural spinal cord compression from metastatic tumor. Diagnosis & Treatment Ann Neurol 3: 40, 1978

    PubMed  Google Scholar 

  58. Black P: Spinal metastases: current status & rec. guidelines for management. Neurosurg 5: 736–746, 1979

    Google Scholar 

  59. Errico TJ, Kostuik JB: Diagnosis & treatment of metastatic disease of the spinal column. A review Contemporary Orthapedics 13: 15–26, 1986

    Google Scholar 

  60. Stark RJ, Jenson BA: Spinal metastases a retrospective survey from a Gen Hosp Brain 105: 189, 1982

    Google Scholar 

  61. Citrin DL, Bessent RG: A comparison of the sensitivity and accuracy of the 99 Tc m-phosphate scan and skeletal radiotherapy in the diagnosis of bone metastases. Clin Radiol 28: 107–117, 1977

    PubMed  Google Scholar 

  62. Redmon J, Spring DB: Spinal computed tomography scanning in the evaluation of metastatic disease. Cancer 18(54) 2: 253–258, 1984

    Google Scholar 

  63. Sarpel S, Sarpel G: Early diagnosis of spinal epidural metastases by magnetic resonance imaging. Cancer 59(6): 1112–1116, 1987

    PubMed  Google Scholar 

  64. Greco A, Palmer MR: Assessment of spinal metastases using the late 26 sequence. Mgn Reson Imaging 7(4): 351–356, 1989

    Google Scholar 

  65. Rodichok LD, Ruchdeschel JC: Early detection and treatment of spinal epidural metastases. The role of myelography. Ann Neurol 20: 696–702, 1986

    PubMed  Google Scholar 

  66. Rao S, Baldini K: Metastatic malignancy of the cervical spine a non operative history. Spine 17(suppl.): S407–412, 1992

    PubMed  Google Scholar 

  67. Blitzer PH: Reanalysis of the RTOG study palliation of symptic osseous metastases. Cancer 55: 1468–1472, 1985

    PubMed  Google Scholar 

  68. Price P, Hoskin PJ: Prospective randomised trial of single and multifraction radiotherapy schedules in the treatment of painful bony metastases. Radiot Oncol 6: 247–255, 1986

    Google Scholar 

  69. Hoskin PJ, Price P: A prospective randomised trial of 4 Gy or 8 Gy single doses in the treatment of metastatic bone pain

  70. Roca EL, Okazaki N: Radiotherapy for bone metastases of hepatocellular carcinoma. Japaneese J of Clin Oncol 22(2): 113–116, 1992

    Google Scholar 

  71. Perez C, Brady L: Principles and practice of radiation oncology. 2nd edition, 1499–1504

  72. Fitzpatrick P, Rider W: Half body radiotherapy. Int J Radiotherapy Oncology Biol Phys vol: 197–207, 1976

  73. Dobbs J, Barrett A: Practicle radiotherapy planning: 237–238, 1978

  74. Nowakowski VA, Castro JR: Charged radiotherapy of paraspinal tumors. Int J Radiotherapy Oncology. Biol Phys 22: 295–303, 1991

    Google Scholar 

  75. Castro JR, Collier JM: Charged particle radiotherapy for lesions encircling the spinal cord or brain stem. Int J Radiotherapy Oncology Biol Phys 17: 477–484, 1989

    Google Scholar 

  76. Porter AT, McEwan AJ: Results of a randomised phase 111 trial to evaluate the efficacy of Strontium-89 as to local beam radiotherapy in the management of endocrine resistant metastatic prostate cancer. Int J Radiotherapy Oncology Biol Phys 25: 805, 1993

    Google Scholar 

  77. Porter A, Mertens W: Strontium-89 for the treatment of metastatic prostate carcinoma. Can J Oncol 1(1): 11, 1991

    Google Scholar 

  78. Ushio Y, Posner R: Experimental spinal cord compression by epidural neoplasm. Neurol 27: 422, 1977

    PubMed  Google Scholar 

  79. Delatte JY, Arbit E: A dose response study of dexamethasone in a model of spinal cord compression caused by epidural tumor. J Neurosurg 70: 920, 1989

    PubMed  Google Scholar 

  80. Vecht CJ, Haaxma, Reiche H: Initial bolus of conventional versus high dose dexamethasone in metastatic spinal cord compression. Neurology 39: 1255, 1989

    PubMed  Google Scholar 

  81. Rubin P: Extradural spinal cord compression by tumor. Part 1 Radiology 93(6): 1243–1248, 1969

    Google Scholar 

  82. Findlay GFC: The role of vertebral collapse in the management of malignant spinal cord compression. J Neuro Neurosurg Psych 50: 151, 1987

    Google Scholar 

  83. Kato A, Ushio Y: Circulatory disturbance of the spinal cord epidural neoplasm in rats. J Neurosurg 63: 260–265, 1985

    PubMed  Google Scholar 

  84. Greeberg HS, Kim JH: Epidural spinal cord compression from metastatic tumor: results with a new treatment protocol. Ann Neurol 8: 361–366, 1980

    PubMed  Google Scholar 

  85. Leviov M, Dale J: The management of metastatic spinal cord compression — A radiotherapeutic success ceiling. Int J Radiotherapy Oncology Biol Phys 27: 231–234, 1993

    Google Scholar 

  86. Marazano E, Latini P: Radiotherapy in metastatic spinal cord compression. Cancer 67: 1311–1317, 1991

    PubMed  Google Scholar 

  87. Juremic B, Grujick D: Radiotherapy of metastatic spinal cord compression. Acta Oncologica 30(8): 985–986, 1991

    PubMed  Google Scholar 

  88. Podd TJ, Carpenter DS: Spinal cord compression prognosis & implications for treatment fractionation. Clin Oncol 4(6): 341–344, 1992

    Google Scholar 

  89. Tang S, Byfield JE: Prognostic factors in the management of metastatic epidural spinal cord compression. J Neurooncol 1(1): 21–28, 1983

    PubMed  Google Scholar 

  90. Barcena AL, Lobato R: Spinal metastatic disease: Analysis of factors determining functional outcome & the choice of treatment. Neurosurg 15(6): 820–827, 1984

    Google Scholar 

  91. Ampil F: Epidural compression from metastatic tumor with resultant paralysis. J Neuro-Oncol 7: 129–136, 1989

    Google Scholar 

  92. Larsen SH, Rasmusseon B: Recovery of gait after radiotherapy in paralytic patients with metastatic epidural spinal cord compression. Neurology 4: 1234–1236, 1990

    Google Scholar 

  93. Kim R: Extradural spinal cord compression from metastatic tumor. Ala Med 60: 10–15, 1990

    PubMed  Google Scholar 

  94. Young RF, Post EM: Treatment of spinal epidural metastases randomised prospective comparison of laminectomy and radiotherapy. J Neurosurg 53: 741–748, 1980

    PubMed  Google Scholar 

  95. Bach F, Argelin N: Metastatic spinal cord compression secondary to lung cancer. J Clin Oncol 10: 1781–1787, 1992

    PubMed  Google Scholar 

  96. Zelefsky M, Scher H: Spinal epidural tumor in patients with prostate cancer. Cancer 70: 2319–2325, 1992

    PubMed  Google Scholar 

  97. Sherman RM, Waddel JP: Laminectomy for metastatic epidural spinal cord tumors. Clin Orthop 207: 55–63, 1986

    PubMed  Google Scholar 

  98. Landmann C, Hunig R: The role of laminectomy in the combined treatment of metastatic spinal cord compression. Int J Radiotherapy Oncology. Biol Phys 24: 627–631, 1992

    Google Scholar 

  99. Grant R. Papadopolous S: Metastatic epidural spinal cord compression. Neurologic Clinics 9(4): 1991

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  1. Department of Radiation Oncology University of Pittsburgh, School of Medicine, 15213, Pittsburgh, P.A., USA

    Clare M. Faul & John C. Flickinger

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Faul, C.M., Flickinger, J.C. The use of radiation in the management of spinal metastases. J Neuro-Oncol 23, 149–161 (1995). https://doi.org/10.1007/BF01053419

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