Summary
Trachea, lung, liver, spleen, pancreas and brain of 77 human patients who had died in the course of clinically diagnosed influenza were subjected to virological and histopathological examination. Type A influenza viruses closely related to the virus variants contemporarily in circulation were isolated from 12 of the lethal cases. In 10 of them, virus was demonstrated in organs other than respiratory, most often the brain. Influenza antigen was also demonstrated in brain tissue by immunofluorescence.
Article PDF
References
Easterday, B. C., Tůmová, B.: Avian influenza viruses. Advances vet. sci. & comp. Med.16, 201–222 (1972).
Edelsen, J. S., Bender, T. R., Chin, T. D. Y.: Encephalopathy and pericarditis during an outbreak of influenza. Amer. J. Epidemiol.100, 79–86 (1974).
Fraňková, V., Rychterová, V.: Inhalatory infection of mice with influenza A0/PR8 virus. II. Detection of the virus in the blood and extrapulmonary organs. Acta virol.19, 35–40 (1975).
Gamboa, E. T., Wolf, A., Yahr, M. D., Harter, D. H., Duffy, P. E., Barden, H., Hsu, K. C.: Influenza virus antigen in postencephalitic parkinsonism brain: detection by immunofluorescence. Arch. Neurol.31, 228–232 (1974).
Ishida, N. T., Morizuka, T., Hinuma, Y.: Virus antigens in kidneys of mice infected with influenza. A. Nature201, 421–422 (1964).
Kerr, A. A., Downhamm, A. P. S., McQuillin, J., Gardener, P. S.: Gastric flu: Influenza B causing abdominal symptoms in children. Lancet7902, 291–295 (1975).
Lehmann, N. L., Gust, I. D.: Viraemia in influenza. A report of two cases. Med. J. Aust.2, 1166–1169 (1971).
Lubkiewicz, K., Elie, K., Spence, L., Marks, M. I.: Laboratory and clinical features of influenza A 2 1971-2 in Montreal. Chest66, 671–674 (1974).
Miyoshi, K., Wolf, A., Harter, D. H., Duffy, P. T., Gamboa, E. T., Hsu, K. C.: Murine influenza virus encephalomyelitis. I. Neuropathological and immunological fluorescence findings. J. Neuropathol. exp. Neurol.32, 51–71 (1973).
Muschner, K., Zotter, S., Ruprecht, E., Liebschen, S.: Tödlich verlaufende zerebrale Grippekomplikationen mit Isolierung von Myxovirus influenzae A2 Hong Kong aus dem Gehirn. Dtsch. Gesundheitswesen27, 213–217 (1972).
Naficy, K.: Human influenza infection with prooved viremia. New Engl. J. Med.269, 964–965 (1963).
Narang, H. K., Field, E. J.: Influenzal encephalitis in mice. A further electron microscopic study. Arch. ges. Virusforsch.42, 160–169 (1973).
Osseason, R., Adelson, L., Kaji, M.: Clinicopathologic study of thirty-three fatal cases of asian influenza. New Engl. J. Med.260, 509–518 (1959).
Pospíšil, Z., Menšík, J., Tůmová, B., Štumpa, A., Černý, M.: Experimental infection of colostrum-deprived, specific pathogen free piglets with A Hong Kong/68 (H3N2) influenza virus. Zbl. Vet. Med.B 20, 139–152 (1973).
Randall, C. F.: Temporary paralysis in childhood after influenza B. Lancet 17898, 107–108 (1975).
Slemons, R. D., Johnson, D. C., Malone, T. G.: Influenza type 4 isolated from imported exotic birds. Avian Dis.17, 458–459 (1973).
Stevens, D., Burmann, D., Clarke, S. C. R., Lamb, R. W., Harper, M. E., Sarafien, A. M.: Temporary paralysis in childhood after influenza B. Lancet 27893, 1354–1355 (1974).
Strnad, P., Tůmová, B., Syrůček, L., Fedová, D., Brůčková, M., Kuncová, L., Střížová, V., Štumpa, A., Berkovičová, V., Losová, M.: Influenza and acute respiratory diseases in the Czechoslovak socialistic republic, 1969–1975. Submitted to Bull. WHO (1976).
Expert committee on respiratory virus diseases. Bull. WHO, Techn. Rep. Ser.170 (1959).
Author information
Authors and Affiliations
Additional information
With 2 Figures
Rights and permissions
About this article
Cite this article
Fraňková, V., Jirásek, A. & Tůmová, B. Type A influenza: Postmortem virus isolations from different organs in human lethal cases. Archives of Virology 53, 265–268 (1977). https://doi.org/10.1007/BF01314671
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01314671