Summary
The measurement of neuron-specific enolase level in serum and cerebrospinal fluid was conducted time-sequentially in an autopsy confirmed patient with Creutzfeld-Jakob disease. The level was markedly high in the early stage of the disease at which time the brain CT showed no or minimal abnormalities, while falling into the normal range in the advanced stage. This is the first report of the elevated level of neuron-specific enolase in Creutzfeldt-Jakob disease.
Similar content being viewed by others
Abbreviations
- CT:
-
Computed tomography
- CSF:
-
Cerebrospinal fluid
- CJD:
-
Creutzfeldt-Jakob disease
- NSE:
-
Neuronspecific enolase
- CEA:
-
Carcinoembryonic antigen
- PSD:
-
Periodic synchronous discharge
- PET:
-
Positron emission tomography
References
Friedland RP, Prusiner SB, Jagust WJ, Budinger TF, Davis RL (1984) Bitemporal hypometabolism in Creutzfeldt-Jakob disease measured by positron emission tomography with [18F]-2-fluorodeoxyglucose. J Comput Assist Tomogr 8:978–981
Hay E, Royds JA, Davies-Jones GAB, Lewtas NA, Timperley WR, Taylor CB (1984) Cerebrospinal fluid enolase in stroke. J Neurol Neurosurg Psychiatry 47:724–729
Marangos PJ, Paul SM (1981) Brain levels of neuron-specific and nonneuronal enolase in Huntington's disease. J Neurochemistry 37:1338–1340
Mokuno K, Kato K, Kawai K, Matsuoka Y, Yanagi T, Sobue I (1983) Neuron-specific enolase and S-100 protein levels in cerebrospinal fluid of patients with various neurological diseases. J Neurol Sci 60:443–451
Peterson PL, Wolfe DE (1985) Creutzfeldt-Jakob Disease — Spongiform change and CSF lactic acidosis: early diagnostic features? Neurology [Suppl 1] 35:181
Royds JA, Parsons MA, Taylor CB, Timperley WR (1982) Enolase isoenzyme distribution in the human brain and its tumors. J Pathol 137:37–49
Royds JA, Davies-Jones GAB, Lewtas NA, Timperley WR, Taylor CB (1983) Enolase isoenzymes in the cerebrospinal fluid of patients with diseases of the nervous system. J Neurol Neurosurg Psychiatry 46:1031–1036
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wakayama, Y., Shibuya, S., Kawase, J. et al. High neuron-specific enolase level of cerebrospinal fluid in the early stage of Creutzfeldt-Jakob disease. Klin Wochenschr 65, 798–801 (1987). https://doi.org/10.1007/BF01743256
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01743256