Abstract
T1 maps of phantoms containing the samples of pure serum or Mn(II)-doped serum at pH=2 were imaged by 1.5 T and 1 T MR Imagers. TheT1 measurements made for the determination of the paramagnetic increase were carried out before and after adding ascorbic acid. The difference of the 1/T1 in samples with and without ascorbic acid was evaluated as the paramagnetic contribution (PMC) of serum iron. As iron content of serum varied from iron deficient to iron overload, the PMC values increased from 0.93 to 0.565 s−1 at 1.5 T and from 0.103 to 0.609 s−1 at 1 T. For confirmative purposes, serum iron of each sample was determined from the paramagnetic contribution and also by an autoanalyzer. The contents of serum iron determined from PMC were in good agreement with those by the autoanalyzer and also with the literature. The data suggest that the paramagnetic contribution of serum iron can be measured by MRI.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kang Y.S., Gore J.C., Armitage I.M.: Magn. Reson. Med.1, 396–409 (1984)
Barnhart J.I., Berk R.N.: Invest. Radiol.21, 132–136 (1986)
Reuben J.: Biochemistry,10, 2834–2838 (1971)
Koenig S.H., Baglin C.M., Brown, III R.D.: Magn. Reson. Med.2, 283 (1985)
Yilmaz A., Otludil B., Batun M.S., Ensari Y., Longo R., Palma L.D.: Phys. Med. Biol.37, 7, 1589–1596 (1992)
Masterson M.E., McGary R., Schmitt K., Koutcher J.A.: Med. Phys.16, 2, 225–233 (1989)
Slone R.M., Fitzsimmons J.R.: Med. Phys.14 1, 131–134 (1987)
Irving M.G., Brereton I.M., Field J., Doddrell D.M.: Magn. Reson. Med.4, 88–92 (1987)
Runge V.M., Clanton J.A., Smith F.W., Hutchison J., Mallard J., Partain C.L., James A.E.: Am. J. Roentgenol.141, 943–984 (1983)
Stark D.D., Moseley M.E., Bacon B.R., Moss A.A., Goldberg H.I., Bass N.M., James T.L.: Radiology154, 137–142 (1985)
Drayer B., Burger P., Darwin R., Riederer S., Herfkens R., Johnson G.A.: Am. J. Roentgenol.147, 103–110 (1986)
Hawrylak N., Ghosh P., Broadus J., Schlueter C., Greenough W.T., Lauterbur P.C.: Exp. Neurol.121, 181–192 (1993)
Milman N., Kirchhoff M.: Ann. Hematol.63, 27–32 (1991)
Unger E.C., Fritz T.A., Palestrant D., Meakem T.J., Granstrom, P., Gatenby R.A.: J. Magn. Reson. Imaging3, 119–124 (1993)
Tamburrini O., Ando S., Della S.M., Maggiolini M., Sessa M.: Radiol. Med. Torino86, 6, 841–846 (1993)
Jensen P.D., Jensen E.T., Christensen T., Ellegaard J.: Br. J. Hematol.87, 1, 171–184 (1994)
Jensen P.D., Jensen E.T., Christensen T., Ellegaard J.: Br. J. Hematol.89, 4, 880–889 (1995)
Grellet J., Bellin M.F., Dion E.: J. Radiol.73, 10, 495–499 (1992)
Chan T.W., Eley C., Liberty P., So A., Kressel H.Y.: Invest. Radiol.27, 6, 443–449 (1992)
Yoshikawa K., Sasaki Y., Ogawa N., Sakuma S.: Nippon Hoshasen Gakkai Zasshi54, 2, 137–153 (1994)
Kjos B.O., Elman RI., Brant-Zawadiski M.: AJMR6, 277 (1985)
Schade A.L., Oyama J., Reinheart R.V., Miller J.R.: Proceedings of the Society for Experimental Biology and Medicine87, 443–448 (1954)
Young D.S., Hicks J.M.: Clin. Pathol.18, 98–102 (1965)
Cook J.D., Fielding J.: Iron (1st edn.), p. 15. New York: Churchill Livingstone 1980.
Yilmaz A., Tez M., Göral V., Boylu S., Kaplan A., Kavak G.: Phys. Med. Biol.41, 539–549 (1996)
Koenig S.H., Brown, III R.D.: Magn. Reson. Med.1, 4, 478–95 (1984)
Andersen C., Jensen F.T.: Magn. Reson. Imaging12, 5, 775–84 (1994)
Harpen M.D., Williams III J.P.: Phys. Med. Biol.32, 421–430 (1987)
Indenkleef J.J.E., Cuppen J.J.M.: Magn. Reson. Med.5, 513–524 (1987)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yilmaz, A., Budak, H. & Longo, R. Paramagnetic contribution of serum iron to the spin-lattice relaxation rate (1/T 1) determined by MRI. Appl. Magn. Reson. 14, 51–58 (1998). https://doi.org/10.1007/BF03162006
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF03162006