Skip to main content
Log in

Glial pathology in development of cerebellar dysplasia in the hereditary cerebellar vermis defect (CVD) rat

  • Regular paper
  • Published:
Acta Neuropathologica Aims and scope Submit manuscript

Abstract

The cerebellar vermis defect (CVD) rat is a new neurological mutant characterized by a cerebellar vermis defect and dysplasia in the cerebellum, especially at the cerebellopontine junctions. In this study, the cytokinetics of glia in terms of the development of cerebellar dysplasia in the CVD rat was investigated using glial fibrillary acidic protein (GFAP) and vimentin immunohistochemistry. In the cerebellar hemispheres, dislocation of the Bergmann glia was observed from postnatal day 5 (P5) in lesions with abnormally aggregated external granule cells (EGCs). Rearranging Bergmann glia were often seen around the EGCs penetrating into the white matter. In the cerebellopontine junctional areas, Bergmann glia were induced after penetration of the Purkinje cells, identified with calbindin immunohistochemistry, and EGCs into the pons from P10. Bergmann fibers were frequently arranged perivascularly. In the clusters of Purkinje cells without EGC settlement in the pons, a small number of Bergmann fibers were observed and their alignment was completely disturbed. These findings suggest that morphological changes in the Bergmann glia depend on their contact with Purkinje cells, but that the orientation of their processes may be influenced by EGC settlement. These glial fibers in the CVD rat may play an important role in the aberrant migration of EGCs, resulting in the development of cerebellar dysplasia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 13 April 1999 / Revised, accepted: 20 July 1999

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kuwamura, M., Morikawa, T., Yamate, J. et al. Glial pathology in development of cerebellar dysplasia in the hereditary cerebellar vermis defect (CVD) rat. Acta Neuropathol 99, 305–309 (2000). https://doi.org/10.1007/PL00007442

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/PL00007442

Navigation