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MTR variations in normal adult brain structures using balanced steady-state free precession

  • Diagnostic Neuroradiology
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Abstract

Introduction

Magnetization transfer (MT) is sensitive to the macromolecular environment of water protons and thereby provides information not obtainable from conventional magnetic resonance imaging (MRI). Compared to standard methods, MT-sensitized balanced steady-state free precession (bSSFP) offers high-resolution images with significantly reduced acquisition times. In this study, high-resolution magnetization transfer ratio (MTR) images from normal appearing brain structures were acquired with bSSFP.

Methods

Twelve subjects were studied on a 1.5 T scanner. MTR values were calculated from MT images acquired in 3D with 1.3 mm isotropic resolution. The complete MT data set was acquired within less than 3.5 min. Forty-one brain structures of the white matter (WM) and gray matter (GM) were identified for each subject.

Results

MTR values were higher for WM than GM. In general, MTR values of the WM and GM structures were in good accordance with the literature. However, MTR values showed more homogenous values within WM and GM structures than previous studies.

Conclusions

MT-sensitized bSSFP provides isotropic high-resolution MTR images and hereby allows assessment of reliable MTR data in also very small brain structures in clinically feasible acquisition times and is thus a promising sequence for being widely used in the clinical routine. The present normative data can serve as a reference for the future characterization of brain pathologies.

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Acknowledgments

The authors would like to thank Thomas Zumbrunn (PhD) and Thomas Fabbro (PhD) for support of statistical analysis.

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Neuroradiology, Institute of Radiology, University of Basel Hospital, Petersgraben 4, 4031, Basel, Switzerland

    Meritxell Garcia, Stephan G. Wetzel & Ernst-Wilhelm Radue

  2. Division of Radiological Physics, Institute of Radiology, University of Basel Hospital, Basel, Switzerland

    Monika Gloor, Oliver Bieri & Klaus Scheffler

Authors
  1. Meritxell Garcia
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  2. Monika Gloor
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  3. Oliver Bieri
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  4. Stephan G. Wetzel
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  5. Ernst-Wilhelm Radue
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  6. Klaus Scheffler
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Corresponding author

Correspondence to Meritxell Garcia.

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Garcia, M., Gloor, M., Bieri, O. et al. MTR variations in normal adult brain structures using balanced steady-state free precession. Neuroradiology 53, 159–167 (2011). https://doi.org/10.1007/s00234-010-0714-5

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  • DOI: https://doi.org/10.1007/s00234-010-0714-5

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