Skip to main content

Advertisement

Log in

Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment

  • Interventional Neuroradiology
  • Published:
Neuroradiology Aims and scope Submit manuscript

Abstract

Introduction

One main complication of a flow-diverting device (FD) in treating intracranial aneurysm is stenosis of parent artery (PA) or occlusion of side branches. The use of a biodegradable device may satisfy the need for aneurysm occlusion and eliminate potential complications.

Methods

Twenty elastase-induced aneurysm rabbit models were divided into three groups: in group 1 (n = 7), polyglycolic acid FDs (PGA-FDs) were implanted across the necks of aneurysms and the abdominal aortas (AA), covering the ostium of a lumbar artery; in group 2 (n = 7), the PGA-FDs were replaced by metal FDs; and in group 3 (n = 6), the PGA-FDs were only implanted across the necks of aneurysms. Animals in group 3 underwent angiography at 6 weeks; those in groups 1 and 2 underwent angiography at 3 months. The status of aneurysm embolization and patency of side branches were assessed.

Results

Complete aneurysm occlusion rates in groups 1 and 3 were 83.3 and 66.7 %, respectively, compared with 0 % in group 2. No side branch occlusions were noted. PA neointimal hyperplasia was minimal, and there were no significant differences between groups 1 and 2 (P = 0.233). The neointimal coverage ratio of the branch ostium in AA in group 1 was not significantly different from that in group 2 (P = 0.605). The neointima comprised predominantly smooth muscle cells and collagen fibers.

Conclusions

The PGA-FD was an effective device for the treatment of aneurysms and was safe for side branches at the 3-month follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Sadasivan C, Cesar L, Seong J et al (2009) An original flow diversion device for the treatment of intracranial aneurysms: evaluation in the rabbit elastase-induced model. Stroke 40:952–958

    Article  PubMed  Google Scholar 

  2. Fischer S, Vajda Z, Aguilar Perez M et al (2012) Pipeline embolization device (PED) for neurovascular reconstruction: initial experience in the treatment of 101 intracranial aneurysms and dissections. Neuroradiology 54:369–382

    Article  PubMed  Google Scholar 

  3. Lubicz B, Collignon L, Raphaeli G et al (2010) Flow-diverter stent for the endovascular treatment of intracranial aneurysms: a prospective study in 29 patients with 34 aneurysms. Stroke 41:2247–2253

    Article  PubMed  Google Scholar 

  4. van Rooij WJ, Sluzewski M (2010) Perforator infarction after placement of a pipeline flow-diverting stent for an unruptured A1 aneurysm. AJNR Am J Neuroradiol 31:E43–E44

    Article  PubMed  Google Scholar 

  5. Fiorella D, Hsu D, Woo HH et al (2010) Very late thrombosis of a pipeline embolization device construct: case report. Neurosurgery 67:onsE313–onsE314

    Article  PubMed  Google Scholar 

  6. Hong B, Wang K, Huang Q et al (2012) Effects of metal coverage rate of flow diversion device on neointimal growth at side branch ostium and stented artery: an animal experiment in rabbit abdominal aorta. Neuroradiology 54:849–855

    Article  PubMed  Google Scholar 

  7. Hofma SH, Whelan DM, van Beusekom HM et al (1998) Increasing arterial wall injury after long-term implantation of two types of stent in a porcine coronary model. Eur Heart J 19:601–609

    Article  PubMed  CAS  Google Scholar 

  8. Hutmacher D, Hürzeler MB, Schliephake H (1996) A review of material properties of biodegradable and bioresorbable polymers and devices for GTR and GBR applications. Int J Oral Maxillofac Implants 11:667–678

    PubMed  CAS  Google Scholar 

  9. Nishio S, Kosuga K, Igaki K et al (2012) Long-term (>10 years) clinical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki–Tamai stents. Circulation 125:2343–2353

    Article  PubMed  CAS  Google Scholar 

  10. Wang K, Huang Q, Hong B et al (2009) Neck injury is critical to elastase-induced aneurysm model. AJNR Am J Neuroradiol 30:1685–1687

    Article  PubMed  CAS  Google Scholar 

  11. Kallmes DF, Ding YH, Dai D et al (2007) A new endoluminal, flow-disrupting device for treatment of saccular aneurysms. Stroke 38:2346–2352

    Article  PubMed  Google Scholar 

  12. Kallmes DF, Ding YH, Dai D et al (2009) A second-generation, endoluminal, flow-disrupting device for treatment of saccular aneurysms. AJNR Am J Neuroradiol 30:1153–1158

    Article  PubMed  CAS  Google Scholar 

  13. Kamran M, Yarnold J, Grunwald IQ et al (2011) Assessment of angiographic outcomes after flow diversion treatment of intracranial aneurysms: a new grading schema. Neuroradiology 53:501–508

    Article  PubMed  Google Scholar 

  14. Wang K, Huang Q, Hong B et al (2012) Correlation of aneurysms occlusion with actual metal coverage at neck after flow-diverting stent implanted in rabbit models. Neuroradiology 54:607–613

    Article  PubMed  Google Scholar 

  15. Lieber BB, Sadasivan C (2010) Endoluminal scaffolds for vascular reconstruction and exclusion of aneurysms from the cerebral circulation. Stroke 41:S21–S25

    Article  PubMed  Google Scholar 

  16. Zilberman M, Nelson KD, Eberhart RC (2005) Mechanical properties and in vitro degradation of bioresorbable fibers and expandable fiber-based stents. J Biomed Mater Res B Appl Biomater 74:792–799

    PubMed  Google Scholar 

  17. Zamiri P, Kuang Y, Sharma U et al (2010) The biocompatibility of rapidly degrading polymeric stents in porcine carotid arteries. Biomaterials 31:7847–7855

    Article  PubMed  CAS  Google Scholar 

  18. Komatsu R, Ueda M, Naruko T et al (1998) Neointimal tissue response at sites of coronary stenting in humans: macroscopic, histological, and immunohistochemical analyses. Circulation 98:224–233

    Article  PubMed  CAS  Google Scholar 

  19. Yokota T, Ichikawa H, Matsumiya G et al (2008) In situ tissue regeneration using a novel tissue-engineered, small-caliber vascular graft without cell seeding. J Thorac Cardiovasc Surg 136:900–907

    Article  PubMed  Google Scholar 

  20. Padfield GJ, Newby DE, Mills NL (2010) Understanding the role of endothelial progenitor cells in percutaneous coronary intervention. J Am Coll Cardiol 55:1553–1565

    Article  PubMed  Google Scholar 

  21. Takahashi H, Yokota T, Uchimura E et al (2009) Newly developed tissue-engineered material for reconstruction of vascular wall without cell seeding. Ann Thorac Surg 88:1269–1276

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by the China Postdoctoral Science Foundation (grant no. 20100481521). We would like to thank MicroPort Medical (Shanghai) Co., Ltd. for the free structures of metal FDs and the delivery systems.

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shaoji Yuan.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, K., Yuan, S., Zhang, X. et al. Biodegradable flow-diverting device for the treatment of intracranial aneurysm: short-term results of a rabbit experiment. Neuroradiology 55, 621–628 (2013). https://doi.org/10.1007/s00234-013-1150-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00234-013-1150-0

Keywords

Navigation