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Whole-brain 320-detector row dynamic volume CT perfusion detected crossed cerebellar diaschisis after spontaneous intracerebral hemorrhage

  • Diagnostic Neuroradiology
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Abstract

Introduction

The purpose of this study was to evaluate the value of 320-detector row CT used to detect crossed cerebellar diaschisis (CCD) in patients with unilateral supratentorial spontaneous intracerebral hemorrhage (SICH).

Methods

We investigated 62 of 156 patients with unilateral supratentorial SICH using 320-detector row CT scanning. Regional cerebral blood flow (rCBF), cerebral blood volume (rCBV), mean transit time (rMTT), and time to peak (rTTP) levels were measured in different regions of interest (ROIs) that were manually outlined on computed tomography perfusion (CTP) for the cerebrum, including normal-appearing brain tissue that surrounded the perilesional low-density area (NA) and the perihematomal low-density area (PA) in all patients and the cerebellum (ipsilateral and contralateral) in CCD-positive patients.

Results

Of 62 cases, a total of 14 met the criteria for CCD due to cerebellar perfusion asymmetry on CTP maps. In the quantitative analysis, significant differences were found in the perfusion parameters between the contralateral and ipsilateral cerebellum in CCD-positive cases. No significant differences were found between the CCD-positive group and the CCD-negative group according to the hematoma volume, NIHSS scores, and cerebral perfusion abnormality (each P > 0.05). The correlation analysis of the degree of NA, PA perfusion abnormality, and the degree of CCD severity showed negative and significant linear correlations (R, −0.66∼−0.56; P < 0.05).

Conclusion

320-detector row CT is a robust and practicable method for the comprehensive primary imaging work-up of CCD in unilateral supratentorial SICH patients.

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Acknowledgments

This study was supported by the Wenzhou Scientific and Technological Cooperation with Foreign Projects (H20090012), Zhejiang Province Science and Technology Project in China (No. 2012C37029) and the Medical Science and Technology Project of Zhejiang Province in China (No. 2014KYA134).

Ethical standards and patient consent

We declare that all human and animal studies have been approved by the Ethics Committee, the First Affiliated Hospital of Wenzhou Medical University (China), and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. We declare that all patients gave informed consent prior to inclusion in this study.

Conflict of interest

We declare that we have no conflict of interest.

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Correspondence to Yun-jun Yang.

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Fu, J., Chen, Wj., Wu, Gy. et al. Whole-brain 320-detector row dynamic volume CT perfusion detected crossed cerebellar diaschisis after spontaneous intracerebral hemorrhage. Neuroradiology 57, 179–187 (2015). https://doi.org/10.1007/s00234-014-1456-6

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  • DOI: https://doi.org/10.1007/s00234-014-1456-6

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