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Although hyposmia or anosmia has been reported in as many as 60% of patients who are symptomatic with COVID-19, imaging of the olfactory nerve is not routinely employed. The olfactory nerve is small and only well seen on dedicated skull base magnetic resonance imaging (MRI), so prospective assessments of its changes have been lacking. We present a case of a COVID-19 patient with anosmia showing atrophy of the olfactory bulbs by MRI in comparison with a pre-symptomatic MRI obtained for an unrelated cause.

A 19-year-old female presented to the otolaryngologist with persistent anosmia after a RT-PCR and serological confirmed diagnosis of COVID-19 1 month prior. At the time of presentation, the patient had a negative RT-PCR and resolution of COVID-19-related respiratory symptoms, but had not recovered her sense of olfaction. The patient underwent a skull base MRI, approximately 2 months after the onset of anosmia. Because of a history of prolactinoma treated medically, the patient had multiple prior MRIs over the course of 4 years. Compared with these multiple prior MRIs, visual and quantitative assessment of a coronal T2 fat-suppressed sequence through the anterior cranial fossa showed new bilateral atrophy of the olfactory bulbs (Fig. 1). The patient’s most recent olfactory bulb volumes measured 3 years before COVID-19-induced anosmia were 49·5 mm3 and 47·46 mm3. In comparison, the olfactory bulb volumes on the MRI after COVID-19-induced anosmia were 29·96 mm3 and 35·51 mm3, smaller than the minimum olfactory bulb volume in the literature of 54 mm3 in women < 45 years of age [1].

Fig. 1
figure 1

Coronal T2 fat-suppressed 3-mm thick images a before and b after diagnosis of COVID-19. Notice the smaller size of olfactory bulbs (anatomic left in yellow arrows) within the olfactory grooves, as evidenced by increased CSF (blue arrows) above the nerve. c Timecourse of patient’s olfactory bulb size over 5 years, with a pronounced decrease on the most recent timepoint on the far right, occurring after diagnosis of COVID-19

Olfactory bulb volume loss in patients within the broad category of post-infectious anosmia is correlated with the duration of olfactory loss [2, 3]. Although the exact pathogenesis of COVID-19-induced anosmia has not been definitively elucidated, Brann et al. suggest that anosmia and dysgeusia in COVID-19 patients may be due to viral infection of the olfactory epithelial support cells such as the sustentacular cells and Bowman’s gland cells [4]. Our results build upon recent imaging findings of the acute inflammatory phase of COVID-19-induced anosmia by showing definitive atrophy compared with baseline imaging [5].

This case highlights a neuroimaging finding in patients with SARS-CoV-2 infection described only once before in the literature [5], with the novel addition of pre-COVID imaging confirming definitive atrophy. A limitation of this case is that the patient did not undergo formal psychophysical testing of her olfactory function. Olfactory bulb atrophy visualized on MR imaging occurs significantly more in patients with objectively measured olfactory dysfunction of various etiologies [6], but currently there are no studies assessing the correlation of olfactory bulb atrophy and objective olfactory tests specifically in COVID-19 patients. Future studies may evaluate changes in olfactory bulb volume in larger cohorts of COVID-19 patients at multiple timepoints with supplementary objective psychophysical olfactory function testing. MR imaging may then allow clinicians to provide patients with a more accurate prognosis regarding olfaction.