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Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI

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Abstract

We report a unique case of cobblestone complex using post-mortem MR and diffusion tensor imaging to assess the laminar organization of the fetal cerebrum. The imaging findings were correlated with autopsy findings. Abnormal cortical development in cobblestone complex resulted in disruption of normal laminar organization of the fetal brain, which was seen as interruption and nodularity of the high-signal T1 cortical band with increased anisotropy and medium diffusivity extending beyond the cortical band into the cerebral mantle on post-mortem MR and diffusion tensor imaging.

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Acknowledgements

This study was supported by the Department of Medical Imaging, University of Toronto, Medical Imaging Research and Development Award.

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Authors and Affiliations

  1. Department of Diagnostic Imaging, Hospital for Sick Children, 555 University Ave., Toronto, Canada, M5G 1X8

    Elysa Widjaja, Sasikhan Geibprasert, Susan Blaser & Tammy Rayner

  2. Department of Pathology, Mount Sinai Hospital, University of Toronto, Toronto, Canada

    Patrick Shannon

Authors
  1. Elysa Widjaja
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  2. Sasikhan Geibprasert
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  3. Susan Blaser
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  4. Tammy Rayner
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  5. Patrick Shannon
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Correspondence to Elysa Widjaja.

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Widjaja, E., Geibprasert, S., Blaser, S. et al. Abnormal fetal cerebral laminar organization in cobblestone complex as seen on post-mortem MRI and DTI. Pediatr Radiol 39, 860–864 (2009). https://doi.org/10.1007/s00247-009-1255-0

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  • DOI: https://doi.org/10.1007/s00247-009-1255-0

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