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Diffusion tensor imaging evaluation of white matter in adolescents with myelomeningocele and Chiari II malformation

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Abstract

Background

Macrostructural abnormalities in cerebral white matter in patients with myelomeningocele are well known, but microstructural abnormalities are not as well studied.

Objective

The aim of this study was to evaluate cerebral white matter in adolescents with myelomeningocele using diffusion tensor imaging (DTI), and to investigate the effects of ventricular dilation and CSF shunt presence on white matter microstructure in these patients.

Materials and methods

DTI and T1-weighted 3-D (T1-3-D) MRI were performed on nine adolescents with myelomeningocele and Chiari II malformation and nine age-matched controls. The fractional anisotropy (FA) and mean diffusivity (MD) values were measured and compared.

Results

Significantly decreased FA and increased MD values were observed in most white matter regions and fibers in adolescents with myelomeningocele compared to controls. Further analysis in patients revealed significant changes in DTI parameters in hemispheres with enlarged lateral ventricles compared to those with normal ventricle size. In addition, a significant difference in FA values in the posterior limb of the internal capsule was found in the comparison of hemispheres in patients with or without CSF shunt catheters.

Conclusion

This study revealed widespread microstructural abnormalities in white matter in adolescents with myelomeningocele and Chiari II malformation. Ventricular dilation may have additional effects on white matter microstructure in this patient population. CSF shunt diversion effects on white matter may be multifactorial and need further investigation.

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Acknowledgement

This research was supported, in part, by the University of Arkansas for Medical Sciences College of Medicine Children’s University Medical Group Grant Program.

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Authors and Affiliations

  1. Department of Radiology, Arkansas Children’s Hospital, Slot 105, Little Rock, AR, 72202, USA

    Xiawei Ou & Charles M. Glasier

  2. Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Xiawei Ou & Charles M. Glasier

  3. Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA

    Jeffrey H. Snow

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  1. Xiawei Ou
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  2. Charles M. Glasier
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  3. Jeffrey H. Snow
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Correspondence to Xiawei Ou.

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Ou, X., Glasier, C.M. & Snow, J.H. Diffusion tensor imaging evaluation of white matter in adolescents with myelomeningocele and Chiari II malformation. Pediatr Radiol 41, 1407–1415 (2011). https://doi.org/10.1007/s00247-011-2180-6

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  • DOI: https://doi.org/10.1007/s00247-011-2180-6

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